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TDP-Glucose disodium salt (CAS 2196-62-5)

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Alternate Names:
TDP-Glucose disodium salt is also known as dTDP-α-D-glucose.
Application:
TDP-Glucose disodium salt is a biosynthetic reagent compound used in the biosynthesis of more rare sugars, like deoxysugars.
CAS Number:
2196-62-5
Purity:
≥95%
Molecular Weight:
608.29
Molecular Formula:
C16H24N2O16P2Na2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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TDP-Glucose disodium salt, often abbreviated as TDP-Glc Na2, plays a role in biochemical research, particularly in studies related to carbohydrate metabolism and bacterial cell wall synthesis. As a thymidine diphosphate glucose compound, it serves as a vital glycosyl donor in enzymatic reactions that are fundamental to the biosynthesis of saccharides and glycoconjugates. The addition of two sodium ions enhances its solubility and stability, making it highly suitable for experimental conditions in vitro. This attribute is especially significant in the enzymatic synthesis of glycolipids and other complex carbohydrates, where TDP-Glucose disodium salt acts as a substrate for various glycosyltransferases. Its utility in studying the molecular pathways of bacterial virulence and the formation of biofilms further underscores its importance in microbial genetics and the development of antibacterial strategies. By facilitating the detailed exploration of glycosylation processes, TDP-Glucose disodium salt contributes significantly to the foundational understanding necessary for advancing the field of molecular biology.


TDP-Glucose disodium salt (CAS 2196-62-5) References

  1. Identification of a gene cluster for antibacterial polyketide-derived antibiotic biosynthesis in the nystatin producer Streptomyces noursei ATCC 11455.  |  Zotchev, S., et al. 2000. Microbiology (Reading). 146 (Pt 3): 611-619. PMID: 10746764
  2. Trehalose biosynthesis in Thermus thermophilus RQ-1: biochemical properties of the trehalose-6-phosphate synthase and trehalose-6-phosphate phosphatase.  |  Silva, Z., et al. 2005. Extremophiles. 9: 29-36. PMID: 15455210
  3. YZGD from Paenibacillus thiaminolyticus, a pyridoxal phosphatase of the HAD (haloacid dehalogenase) superfamily and a versatile member of the Nudix (nucleoside diphosphate x) hydrolase superfamily.  |  Tirrell, IM., et al. 2006. Biochem J. 394: 665-74. PMID: 16336194
  4. A two-stage one-pot enzymatic synthesis of TDP-L-mycarose from thymidine and glucose-1-phosphate.  |  Takahashi, H., et al. 2006. J Am Chem Soc. 128: 1432-3. PMID: 16448097
  5. Genetically engineered biosynthesis of macrolide derivatives including 4-amino-4,6-dideoxy-L-glucose from Streptomyces venezuelae YJ003-OTBP3.  |  Pageni, BB., et al. 2008. J Microbiol Biotechnol. 18: 88-94. PMID: 18239422
  6. In silico biosynthesis of virenose, a methylated deoxy-sugar unique to Coxiella burnetii lipopolysaccharide.  |  Flores-Ramirez, G., et al. 2012. Proteome Sci. 10: 67. PMID: 23150954
  7. Submicroscopic deletions at 13q32.1 cause congenital microcoria.  |  Fares-Taie, L., et al. 2015. Am J Hum Genet. 96: 631-9. PMID: 25772937
  8. Altering UDP-glucose Donor Substrate Specificity of Bacillus licheniformis Glycosyltransferase towards TDP-glucose.  |  Cho, KW., et al. 2019. J Microbiol Biotechnol. 29: 268-273. PMID: 30602272
  9. NADP dependent oxidation of TDP-glucose by an enzyme system from sugar beets.  |  Katan, R. and Avigad, G. 1966. Biochem Biophys Res Commun. 24: 18-24. PMID: 4381717
  10. Cloning of the genes encoding thymidine diphosphoglucose 4,6-dehydratase and thymidine diphospho-4-keto-6-deoxyglucose 3,5-epimerase from the erythromycin-producing Saccharopolyspora erythraea.  |  Linton, KJ., et al. 1995. Gene. 153: 33-40. PMID: 7883182
  11. Analysis of five tylosin biosynthetic genes from the tyllBA region of the Streptomyces fradiae genome.  |  Merson-Davies, LA. and Cundliffe, E. 1994. Mol Microbiol. 13: 349-55. PMID: 7984112
  12. Purification and characterization of UDP-glucose:ceramide glucosyltransferase from rat liver Golgi membranes.  |  Paul, P., et al. 1996. J Biol Chem. 271: 2287-93. PMID: 8567691
  13. Characterization of sucrose synthase from rice grains for the enzymatic synthesis of UDP and TDP glucose  |  Lothar Elling Maria-Regina Kula. October 1995,. Enzyme and Microbial Technology. Volume 17, Issue 10,: Pages 929-934.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

TDP-Glucose disodium salt, 5 mg

sc-286785B
5 mg
$312.00

TDP-Glucose disodium salt, 10 mg

sc-286785C
10 mg
$468.00

TDP-Glucose disodium salt, 25 mg

sc-286785
25 mg
$832.00

TDP-Glucose disodium salt, 50 mg

sc-286785A
50 mg
$1457.00

TDP-Glucose disodium salt, 100 mg

sc-286785D
100 mg
$2913.00