Tctex1 Antibody (H-11): sc-365567
- Tctex1 Antibody (H-11) is a mouse monoclonal IgG2b κ Tctex1 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1-60 mapping at the N-terminus of Tctex1 of human origin
- Tctex1 Antibody (H-11) is recommended for detection of Tctex1 of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Tctex1 Antibody (H-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Tctex1 Antibody (H-11). This work is in progress.
QUICK LINKS
Tctex1 Antibody (H-11) is a mouse monoclonal IgG2b kappa light chain antibody that detects Tctex1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Tctex1 (H-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Tctex1, also known as CW-1 or TCTEL1, is a cytoplasmic dynein light chain that plays a crucial role in the transport of cellular cargo along microtubules, which is essential for maintaining cellular organization and function. Tctex1 is expressed in various human tissues, including the heart, placenta, skeletal muscle, kidney, pancreas, spleen, prostate, testis, ovary, ileum, and colon, highlighting its importance in diverse physiological processes. Tctex1 interacts with other proteins such as Na+ CP type Xα (SCN10A) and is regulated by several key proteins, including dynactin, LIS1, and NudEL (NudE-like), which modulate dynein activity and ensure proper cellular transport mechanisms. The carboxy terminus of dynein, where Tctex1 is located, is particularly important for microtubule-dependent motility and is highly conserved across species, underscoring the evolutionary significance of Tctex1 in cellular dynamics.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Tctex1 Antibody (H-11) References:
- The dynein heavy chain family. | Asai, DJ. and Wilkes, DE. 2004. J Eukaryot Microbiol. 51: 23-9. PMID: 15068262
- High speed sliding of axonemal microtubules produced by outer arm dynein. | Seetharam, RN. and Satir, P. 2005. Cell Motil Cytoskeleton. 60: 96-103. PMID: 15605357
- The offloading model for dynein function: differential function of motor subunits. | Lee, WL., et al. 2005. J Cell Biol. 168: 201-7. PMID: 15642746
- Role of cytoplasmic dynein in the axonal transport of microtubules and neurofilaments. | He, Y., et al. 2005. J Cell Biol. 168: 697-703. PMID: 15728192
- NudEL targets dynein to microtubule ends through LIS1. | Li, J., et al. 2005. Nat Cell Biol. 7: 686-90. PMID: 15965467
- The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth. | Chuang, JZ., et al. 2005. Dev Cell. 9: 75-86. PMID: 15992542
- Cytoplasmic dynein nomenclature. | Pfister, KK., et al. 2005. J Cell Biol. 171: 411-3. PMID: 16260502
- Dynein motility: four heads are better than two. | McGrath, JL. 2005. Curr Biol. 15: R970-2. PMID: 16332531
- Genetic analysis of the cytoplasmic dynein subunit families. | Pfister, KK., et al. 2006. PLoS Genet. 2: e1. PMID: 16440056
- Tctex1 plays a key role in the α-synuclein autophagy lysosomal degradation pathway. | Dong, S., et al. 2017. Neurosci Lett. 661: 90-95. PMID: 28970129
- Silencing of Tctex1 impairs autophagy lysosomal degradation of α-synuclein and cell viability. | Zhang, Y., et al. 2018. Neuroreport. 29: 385-392. PMID: 29406369
- Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q. | Watanabe, TK., et al. 1996. Cytogenet Cell Genet. 73: 153-6. PMID: 8646886
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tctex1 Antibody (H-11) | sc-365567 | 200 µg/ml | $316.00 | |||
Tctex1 Antibody (H-11) AC | sc-365567 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Tctex1 Antibody (H-11) HRP | sc-365567 HRP | 200 µg/ml | $316.00 | |||
Tctex1 Antibody (H-11) FITC | sc-365567 FITC | 200 µg/ml | $330.00 | |||
Tctex1 Antibody (H-11) PE | sc-365567 PE | 200 µg/ml | $343.00 | |||
Tctex1 Antibody (H-11) Alexa Fluor® 488 | sc-365567 AF488 | 200 µg/ml | $357.00 | |||
Tctex1 Antibody (H-11) Alexa Fluor® 546 | sc-365567 AF546 | 200 µg/ml | $357.00 | |||
Tctex1 Antibody (H-11) Alexa Fluor® 594 | sc-365567 AF594 | 200 µg/ml | $357.00 | |||
Tctex1 Antibody (H-11) Alexa Fluor® 647 | sc-365567 AF647 | 200 µg/ml | $357.00 | |||
Tctex1 Antibody (H-11) Alexa Fluor® 680 | sc-365567 AF680 | 200 µg/ml | $357.00 | |||
Tctex1 Antibody (H-11) Alexa Fluor® 790 | sc-365567 AF790 | 200 µg/ml | $357.00 |