Date published: 2025-10-19

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TCS OX2 29 (CAS 372523-75-6)

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Alternate Names:
(2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanone hydrochloride
Application:
TCS OX2 29 is an inhibitor of the orexin R-2 receptor
CAS Number:
372523-75-6
Purity:
≥99%
Molecular Weight:
433.97
Molecular Formula:
C23H31N3O3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Potent orexin 2 receptor (OX2) antagonist (IC50 = 40 nM) that displays > 250 fold selectivity over OX1 and over 50 other ion channels, receptors and transporters.


TCS OX2 29 (CAS 372523-75-6) References

Hirose et al (2003) N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: The first orexin-2 receptor selective non-peptidic antagonist. Bioorg.Med.Chem.Lett. 13 4497.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

TCS OX2 29, 10 mg

sc-204329
10 mg
$185.00

TCS OX2 29, 50 mg

sc-204329A
50 mg
$781.00