Molecular structure of TCS 46b, CAS Number: 302799-86-6
TCS 46b (CAS 302799-86-6)
Application:
TCS 46b is a subtype-selective NR1A/NR2B NMDA receptor antagonist
CAS Number:
302799-86-6
Purity:
>98%
Molecular Weight:
345.44
Molecular Formula:
C22H23N3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Orally active, subtype-selective NR1A/NR2B NMDA receptor antagonist (IC50 values are 5.3, 35000 and > 100000 nM for NR1A/2B, NR1A/2A and NR1A/2C receptor subtypes respectively). Potentiates the effect of L-DOPA in 6-OHDA-lesioned rats following oral administration.
TCS 46b (CAS 302799-86-6) References
Wright et al (2000) Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(heteroarylalkynyl)-4-benzylpiperidines. J.Med.Chem. 43 3408. Roger et al (2003) Synthesis, radiosynthesis and in vivo evaluation of 5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-1,3-dihydrobenzoimidazol-2-[11C]one, as a potent NR1A/2B subtype selective NMDA PET radiotracer. Bioorg.Med.Chem. 11 5401.Inhibitor of:
NMDA epsilon 2, and NMDA zeta 1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TCS 46b, 10 mg | sc-204328 | 10 mg | $149.00 | |||
TCS 46b, 50 mg | sc-204328A | 50 mg | $630.00 |