Molecular structure of TCS 401, CAS Number: 243966-09-8
TCS 401 (CAS 243966-09-8)
See product citations (3)
Alternate Names:
2-[(Carboxycarbonyl)amino]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid hydrochloride
Application:
TCS 401 is a selective inhibitor of PTP1B (protein-tyrosine phosphatase 1B)
CAS Number:
243966-09-8
Purity:
≥95%
Molecular Weight:
306.72
Molecular Formula:
C10H10N2O5S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
TCS 401 is a selective inhibitor of PTP1B (protein-tyrosine phosphatase 1B). TCS 401 is a compound of interest in biochemical research, particularly in the study of receptor-ligand interactions. It is utilized to probe the binding affinity and intrinsic activity at specific receptor sites, enabling researchers to better understand receptor dynamics and signaling pathways. In molecular biology, TCS 401 is applied to investigate gene expression modulation, as it can influence transcription factors and downstream target genes. Additionally, this chemical serves as a tool in neurobiological studies, providing insights into neurotransmitter regulation and synaptic plasticity.
TCS 401 (CAS 243966-09-8) References
- Store-operated Ca2+ entry in hippocampal neurons: Regulation by protein tyrosine phosphatase PTP1B. | Koss, DJ., et al. 2013. Cell Calcium. 53: 125-38. PMID: 23218930
- Necrotic renal epithelial cell inhibits renal interstitial fibroblast activation: role of protein tyrosine phosphatase 1B. | Ponnusamy, M., et al. 2013. Am J Physiol Renal Physiol. 304: F698-709. PMID: 23283996
- Adiponectin inhibits leptin-induced oncogenic signalling in oesophageal cancer cells by activation of PTP1B. | Beales, ILP., et al. 2014. Mol Cell Endocrinol. 382: 150-158. PMID: 23994026
- Protein tyrosine phosphatase 1B regulates the activity of retinal pigment epithelial cells. | Du, ZD., et al. 2015. Mol Vis. 21: 523-31. PMID: 25999679
- High-Fat-Diet-Induced Deficits in Dopamine Terminal Function Are Reversed by Restoring Insulin Signaling. | Fordahl, SC. and Jones, SR. 2017. ACS Chem Neurosci. 8: 290-299. PMID: 27966885
- Inhibiting Protein Tyrosine Phosphatase 1B to Improve Regenerative Functions of Endothelial Cells. | Wang, Y., et al. 2018. J Cardiovasc Pharmacol. 71: 59-64. PMID: 28817487
- The HSV-1 mechanisms of cell-to-cell spread and fusion are critically dependent on host PTP1B. | Carmichael, JC., et al. 2018. PLoS Pathog. 14: e1007054. PMID: 29742155
- Affinities and Comparisons of Enzyme States by Principal Component Analysis of NMR Spectra, Automated using TREND Software. | Xu, J. and Van Doren, SR. 2018. Methods Enzymol. 607: 217-240. PMID: 30149859
- Angiotensin II induces apoptosis of cardiac microvascular endothelial cells via regulating PTP1B/PI3K/Akt pathway. | Wang, Y., et al. 2019. In Vitro Cell Dev Biol Anim. 55: 801-811. PMID: 31502193
- Exploring the allosteric mechanism of protein tyrosine phosphatase 1B by molecular dynamics simulations. | Wang, Q., et al. 2020. J Biomol Struct Dyn. 38: 4040-4047. PMID: 31625458
- Inhibition of protein-tyrosine phosphatase 1B phosphorylation enhances early adhesion of mesenchymal stem cells to facilitate fabrication of tissue-engineered bone. | Luo, K., et al. 2020. J Tissue Eng Regen Med. 14: 575-587. PMID: 32061178
- New insights into TNFα/PTP1B and PPARγ pathway through RNF213- a link between inflammation, obesity, insulin resistance, and Moyamoya disease. | Sarkar, P. and Thirumurugan, K. 2021. Gene. 771: 145340. PMID: 33333224
- Tubeimoside I Inhibits Cell Proliferation and Induces a Partly Disrupted and Cytoprotective Autophagy Through Rapidly Hyperactivation of MEK1/2-ERK1/2 Cascade via Promoting PTP1B in Melanoma. | Du, J., et al. 2020. Front Cell Dev Biol. 8: 607757. PMID: 33392197
- Conserved conformational dynamics determine enzyme activity. | Torgeson, KR., et al. 2022. Sci Adv. 8: eabo5546. PMID: 35921420
Inhibitor of:
PTP1B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TCS 401, 10 mg | sc-204327 | 10 mg | $257.00 | |||
| US: Only available in the US | ||||||