TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) (Ki values are 0.29, 59, 560, 1100, > 2000, > 2000 and > 2000 μM for PTP1B, CD45 D1D2, PTPβ, PTPε D1, SHP-1, PTPα D1 and LAR D1D2 respectively).
1. Iversen, L.F., et al. 2000. J. Biol. Chem. 275: 10300-10305. PMID: 10744717 2. Andersen, H.S., et al. 2002. J. Med. Chem. 45: 4443-4459. PMID: 12238924
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Du et alDu et al. (PubMed ID 25999679) found that TCS-401 promoted the proliferation and expression of cyclin A and cyclin D1 in rat retinal pigment epithelium (RPE) cells. -SCBT Publication Review
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