TCS 401 CAS: 243966-09-8
MF: C10H10N2O5S•HCl
MW: 306.72
A selective inhibitor of protein-tyrosine phosphatase 1B.

TCS 401 (CAS 243966-09-8)

TCS 401 | CAS 243966-09-8 is rated 5.0 out of 5 by 1.
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Synonym: 2-[(Carboxycarbonyl)amino]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid hydrochloride
Application: A selective inhibitor of protein-tyrosine phosphatase 1B
CAS Number: 243966-09-8
Purity: >98%
Molecular Weight: 306.72
Molecular Formula: C10H10N2O5S•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) (Ki values are 0.29, 59, 560, 1100, > 2000, > 2000 and > 2000 μM for PTP1B, CD45 D1D2, PTPβ, PTPε D1, SHP-1, PTPα D1 and LAR D1D2 respectively).


References

1. Iversen, L.F., et al. 2000. J. Biol. Chem. 275: 10300-10305. PMID: 10744717
2. Andersen, H.S., et al. 2002. J. Med. Chem. 45: 4443-4459. PMID: 12238924

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mM).
Storage :
Desiccate at room temperature
Ki Data :
PTP1B: Ki= 0.29 µM; CD45 D1D2: Ki= 59 µM; PTPβ: Ki= 560 µM; PTPε D1: Ki= 1100 µM; SHP-1: Ki= > 2000 µM; PTPα D1: Ki= > 2000 µM; LAR D1D2: Ki= > 2000 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
56972185
SMILES :
C1CNCC2=C1C(=C(S2)NC(=O)C(=O)O)C(=O)O.Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Du et al Du et al. (PubMed ID 25999679) found that TCS-401 promoted the proliferation and expression of cyclin A and cyclin D1 in rat retinal pigment epithelium (RPE) cells. -SCBT Publication Review
Date published: 2015-04-17
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