Molecular structure of TCS 2510, CAS Number: 346673-06-1
TCS 2510 (CAS 346673-06-1)
See product citations (2)
Alternate Names:
5-[(3S)-3-hydroxy-4-phenyl-1-buten-1-yl]1-[6-(2H-tetrazol-5R-yl)hexyl]-2-pyrrolidinone
Application:
TCS 2510 is a selective agonist of EP4
CAS Number:
346673-06-1
Molecular Weight:
383.49
Molecular Formula:
C21H29N5O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
TCS 2510 is a selective agonist of EP4. Research indicates that the compound does not bind at other prostaglandin receptors with concentrations as high as 14 µM.
TCS 2510 (CAS 346673-06-1) References
- Prostaglandin E(2) mediates proliferation and chloride secretion in ADPKD cystic renal epithelia. | Liu, Y., et al. 2012. Am J Physiol Renal Physiol. 303: F1425-34. PMID: 22933297
- Nature of the slow relaxation of smooth muscle induced by a EP2 receptor agonist with a non-prostanoid structure. | Jones, RL., et al. 2013. Prostaglandins Leukot Essent Fatty Acids. 88: 321-30. PMID: 23419768
- EP2 receptor activates dual G protein signaling pathways that mediate contrasting proinflammatory and relaxatory responses in term pregnant human myometrium. | Kandola, MK., et al. 2014. Endocrinology. 155: 605-17. PMID: 24265450
- Role of prostaglandins in spinal transmission of the exercise pressor reflex in decerebrated rats. | Stone, AJ., et al. 2014. Neuroscience. 277: 26-35. PMID: 25003710
- Assessing the agonist profiles of the prostacyclin analogues treprostinil and naxaprostene, particularly their DP₁ activity. | Syed, NI. and Jones, RL. 2015. Prostaglandins Leukot Essent Fatty Acids. 95: 19-29. PMID: 25542069
- Prostaglandin E2 inhibits mast cell-dependent bronchoconstriction in human small airways through the E prostanoid subtype 2 receptor. | Säfholm, J., et al. 2015. J Allergy Clin Immunol. 136: 1232-9.e1. PMID: 25962903
- Focal adhesion kinase signaling regulates anti-inflammatory function of bone marrow mesenchymal stromal cells induced by biomechanical force. | Lee, HJ., et al. 2017. Cell Signal. 38: 1-9. PMID: 28647573
- Selective inhibition of histamine-evoked Ca2+ signals by compartmentalized cAMP in human bronchial airway smooth muscle cells. | Dale, P., et al. 2018. Cell Calcium. 71: 53-64. PMID: 29604964
- Regulatory effect of PGE2 on microbicidal activity and inflammatory cytokines in canine leishmaniasis. | Venturin, GL., et al. 2020. Parasite Immunol. 42: e12713. PMID: 32173875
- Prostaglandin E2 receptors and their role in gastrointestinal motility - Potential therapeutic targets. | Heeney, A., et al. 2021. Prostaglandins Other Lipid Mediat. 152: 106499. PMID: 33035691
- PGE2 upregulates the Na+/K+ ATPase in HepG2 cells via EP4 receptors and intracellular calcium. | Hodeify, R., et al. 2021. PLoS One. 16: e0245400. PMID: 33444342
- Prostaglandin E2 and Its Receptor EP2 Modulate Macrophage Activation and Fusion in Vitro. | Saleh, LS., et al. 2020. ACS Biomater Sci Eng. 6: 2668-2681. PMID: 33463295
- Prostaglandin E2 Receptor 4 (EP4) Affects Trophoblast Functions via Activating the cAMP-PKA-pCREB Signaling Pathway at the Maternal-Fetal Interface in Unexplained Recurrent Miscarriage. | Peng, L., et al. 2021. Int J Mol Sci. 22: PMID: 34502044
Inhibitor of:
EP3, and EP4.Activator of:
EP4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TCS 2510, 1 mg | sc-361377 | 1 mg | $213.00 |