Molecular structure of TCS 2002, CAS Number: 1005201-24-0
TCS 2002 (CAS 1005201-24-0)
Application:
TCS 2002 is a cell-permeable inhibitor of GSK-3β
CAS Number:
1005201-24-0
Purity:
≥99%
Molecular Weight:
338.38
Molecular Formula:
C18H14N2O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
TCS 2002 is a cell-permeable oxadiazolo-benzofuranylphenylsulfoxide that inhibits GSK-3β (IC50 = 35, 34, and 140 nM using the racemate, the (S), and the (R) enantiomer, respectively) in a highly selective manner. TCS 2002 is shown to be orally active and significantly reduce CWS-induced brain tau Thr205 phosphorylation.
TCS 2002 (CAS 1005201-24-0) References
- 2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta with good brain permeability. | Saitoh, M., et al. 2009. J Med Chem. 52: 6270-86. PMID: 19775160
- Hypothermic Preconditioning Reverses Tau Ontogenesis in Human Cortical Neurons and is Mimicked by Protein Phosphatase 2A Inhibition. | Rzechorzek, NM., et al. 2016. EBioMedicine. 3: 141-154. PMID: 26870825
- Novel Non-phosphorylated Serine 9/21 GSK3β/α Antibodies: Expanding the Tools for Studying GSK3 Regulation. | Grabinski, T. and Kanaan, NM. 2016. Front Mol Neurosci. 9: 123. PMID: 27909397
- Mitochondria-Endoplasmic Reticulum Contact Sites Function as Immunometabolic Hubs that Orchestrate the Rapid Recall Response of Memory CD8+ T Cells. | Bantug, GR., et al. 2018. Immunity. 48: 542-555.e6. PMID: 29523440
Inhibitor of:
GSK-3 beta.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TCS 2002, 10 mg | sc-359020 | 10 mg | $175.00 |