TCR V β 5 Antibody (6D792): sc-73128
- TCR V β 5 Antibody (6D792) is a mouse monoclonal IgG2a TCR V β 5 antibody provided at 100 µg/ml
- raised against human thymoma cell line, HPB-ALL of human origin
- recommended for detection of the V β 5 variant of TCRβ of human origin of human origin by WB, IP and FCM
- also provided azide-free for activating T cells (V beta 5-related subset), sc-73128 L, 100 µg/0.1 ml
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TCR V β 5 Antibody (6D792). This work is in progress.
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TCR V β 5 Antibody (6D792) is a mouse monoclonal IgG2a antibody that detects TCR V beta 5 protein of human origin by western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). Anti-TCR V beta 5 antibody (6D792) is available as the non-conjugated format. The T cell antigen receptor (TCR) plays a crucial role in the immune response by recognizing foreign antigens and initiating intracellular signaling pathways that lead to T cell activation. TCR is a heterodimer composed of either alpha and beta or gamma and delta chains, with the majority of circulating T cells (approximately 95%) expressing the alpha/beta heterodimer. This diversity in TCR specificity is essential for the immune system to effectively recognize a wide array of antigens, achieved through the somatic recombination of variable (V), diversity (D), and joining (J) gene segments during T cell development. The genes encoding TCR beta and gamma chains are located in distinct loci, while the alpha and delta chain genes are found within a single locus. The process of T cell development involves the synthesis of the beta chain by first joining a D segment with a J segment, followed by the addition of a V segment to form the complete D-J-V gene, and finally incorporating a constant (C) segment. Notably, genetic mutations in TCR beta locus have been linked to the development of T cell lymphomas, highlighting the importance of TCR integrity in maintaining immune health.
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TCR V β 5 Antibody (6D792) References:
- Expansions of CD8+CD28- and CD8+TcRVbeta5.2+ T cells in peripheral blood of heavy alcohol drinkers. | Arosa, FA., et al. 2000. Alcohol Clin Exp Res. 24: 519-27. PMID: 10798589
- HLA-DQ beta chain can present mouse endogenous provirus MTV-9 product and clonally delete Tcr V beta 5+ and V beta 11+ T cells in transgenic mice. | Zhou, P., et al. 1992. Immunogenetics. 35: 219-23. PMID: 1311702
- Evidence for a role for T cell receptors (TCR) in the effector phase of acute bone marrow graft rejection. TCR V beta 5 transgenic mice lack effector cells able to cause graft rejection. | Kikly, K. and Dennert, G. 1992. J Immunol. 149: 3489-94. PMID: 1431119
- Expression of a murine polyclonal T cell receptor marker correlates with the use of specific members of the V beta 8 gene segment subfamily. | Behlke, MA., et al. 1987. J Exp Med. 165: 257-62. PMID: 2432150
- Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor. | Staerz, UD., et al. 1985. J Immunol. 134: 3994-4000. PMID: 2580901
- Methods for the selection and growth of antigen-specific cytolytic T lines and clones bearing a defined T cell receptor beta chain marker. | Ito, M., et al. 1987. J Immunol Methods. 103: 229-37. PMID: 2959725
- Expanded TcR V beta 5.1 family in a diffuse high-grade B cell immunoblastic lymphoma. | Hodges, E., et al. 1995. Leukemia. 9: 1108-12. PMID: 7596179
- A mouse monoclonal antibody specific for the V beta 5.3 chain of the human TcR recognizes a subgroup of the mouse TcR V beta 8.2 chains. | Bleux, C., et al. 1995. J Leukoc Biol. 57: 491. PMID: 7884322
- Dominant V beta 8 gene usage in response to TNP: failure to use other V beta chains following removal of V beta 8+ T cells by monoclonal antibody in vivo. | Dieli, F., et al. 1994. Immunology. 82: 99-105. PMID: 8045598
- T cell vaccination against autoimmune diabetes in nonobese diabetic mice. | Formby, B. and Shao, T. 1993. Ann Clin Lab Sci. 23: 137-47. PMID: 8096128
- Involvement of TCR-V beta 8.3+ cells in the cure of mice bearing a large MOPC-315 tumor by low dose melphalan. | Mokyr, MB., et al. 1993. J Immunol. 151: 4838-46. PMID: 8409442
- T cell receptor V beta 5 and V beta 17 clonal diversity in cerebrospinal fluid and peripheral blood lymphocytes of multiple sclerosis patients. | Lozeron, P., et al. 1998. Mult Scler. 4: 154-61. PMID: 9762666
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TCR V β 5 Antibody (6D792) | sc-73128 | 100 µg/ml | $322.00 | |||
TCR V β 5 Antibody (6D792) L | sc-73128 L | 100 µg/0.1 ml | $322.00 |