TCR γ/δ Antibody (UC7-13D5): sc-19608

TCR γ/δ Antibody (UC7-13D5) is a hamster monoclonal IgG antibody that detects TCR γ and TCR δ proteins of mouse origin by immunofluorescence (IF) and flow cytometry (FCM). TCR γ/δ (UC7-13D5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The T cell antigen receptor (TCR) plays a crucial role in the immune response by recognizing foreign antigens and initiating intracellular signaling that activates T cells, transitioning them from a dormant state to an active one. The TCR is a heterodimer composed of either alpha and beta or gamma and delta chains, with the majority of T cells (approximately 95%) expressing the alpha/beta heterodimer, while only about 2-5% express the gamma/delta variant. This distinction is significant as TCR γ/δ T cells respond to a broader range of antigens, including non-peptide antigens, which can be critical in various immune responses, particularly in mucosal immunity and in recognizing stressed or infected cells. Additionally, the TCR requires the presence of CD3 chains and either CD4 or CD8 co-receptors for effective signal transduction, allowing for the differentiation of T helper cells, which express CD4, from T cytotoxic cells, which express CD8. The TCR, in conjunction with CD4, binds to class II major histocompatibility complex (MHC) molecules presented by antigen-presenting cells, enhancing the interaction′s avidity and ensuring a robust immune response.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

TCR γ/δ Antibody (UC7-13D5) References:

1. Tissue-specific segregation of TCRgamma delta+ NKT cells according to phenotype TCR repertoire and activation status: parallels with TCR alphabeta+NKT cells.  |  Lees, RK., et al. 2001. Eur J Immunol. 31: 2901-9. PMID: 11592065
2. Immature thymocytes that fail to express TCRbeta and/or TCRgamma delta proteins die by apoptotic cell death in the CD44(-)CD25(-) (DN4) subset.  |  Falk, I., et al. 2001. Eur J Immunol. 31: 3308-17. PMID: 11745348
3. Gene regulation within the TCR-alpha/delta locus by specific deletion of the TCR-delta cluster.  |  de Villartay, JP. and Cohen, DI. 1990. Res Immunol. 141: 618-23. PMID: 2151349
4. RUNX1-dependent RAG1 deposition instigates human TCR-δ locus rearrangement.  |  Cieslak, A., et al. 2014. J Exp Med. 211: 1821-32. PMID: 25135298
5. Aberrant TCRδ rearrangement underlies the T-cell lymphocytopenia and t(12;14) translocation associated with ATM deficiency.  |  Jiang, W., et al. 2015. Blood. 125: 2665-8. PMID: 25721125
6. A discrete chromatin loop in the mouse Tcra-Tcrd locus shapes the TCRδ and TCRα repertoires.  |  Chen, L., et al. 2015. Nat Immunol. 16: 1085-93. PMID: 26258942
7. mTORC1 in Thymic Epithelial Cells Is Critical for Thymopoiesis, T-Cell Generation, and Temporal Control of γδT17 Development and TCRγ/δ Recombination.  |  Wang, HX., et al. 2016. PLoS Biol. 14: e1002370. PMID: 26889835
8. Ancient Use of Ig Variable Domains Contributes Significantly to the TCRδ Repertoire.  |  Deiss, TC., et al. 2019. J Immunol. 203: 1265-1275. PMID: 31341077
9. Durable Expansion of TCR-δ Meta-Clonotypes After BCG Revaccination in Humans.  |  James, CA., et al. 2022. Front Immunol. 13: 834757. PMID: 35432299
10. Interleukin-7 receptor signaling is crucial for enhancer-dependent TCRδ germline transcription mediated through STAT5 recruitment.  |  Rodríguez-Caparrós, A., et al. 2022. Front Immunol. 13: 943510. PMID: 36059467

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TCR γ/δ Antibody (UC7-13D5) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-TCR γ/δ Antibody (UC7-13D5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TCR γ/δ Antibody (UC7-13D5) Specifications

Alternate Product Name: TCR γ/δ

Product Clone Name: UC7-13D5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG

Amino Acids:

Epitope Target: TCR γ/δ

Epitope Species: mouse

Product Reactivity/Detection: TCR γ and TCR δ

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, FCM

Vialing Information: Each vial contains 200 µg IgG in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for TCR γ/δ Antibody (UC7-13D5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin