TCR γ/δ Antibody (GL3): sc-59380

TCR γ/δ Antibody (GL3) is a hamster monoclonal IgG antibody that detects TCR γ/δ in mouse samples through immunofluorescence (IF) and flow cytometry (FCM) applications. TCR γ/δ is a crucial component of the immune system, primarily expressed on a subset of T cells that play a significant role in the recognition of non-peptide antigens, such as those derived from microbial sources. Unlike the more common TCR α/β, TCR γ/δ T cells are known for their ability to respond rapidly to infections and stress signals, making these cells essential for the early immune response. TCR γ/δ T cells are predominantly located in epithelial tissues, such as the skin and gut, where these cells contribute to the first line of defense against pathogens. The unique localization of TCR γ/δ T cells allows direct interaction with infected or transformed cells, facilitating immediate immune responses. TCR γ/δ T cells can produce a variety of cytokines and chemokines, further enhancing their role in immune regulation and tissue homeostasis. Anti-TCR γ/δ antibody (GL3) is an invaluable tool for researchers studying the dynamics of these specialized T cells and their contributions to immune responses in various disease contexts.

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TCR γ/δ Antibody (GL3) References:

1. The TCR-delta repertoire in normal human skin is restricted and distinct from the TCR-delta repertoire in the peripheral blood.  |  Holtmeier, W., et al. 2001. J Invest Dermatol. 116: 275-80. PMID: 11180004
2. Disruption of the RanBP17/Hox11L2 region by recombination with the TCRdelta locus in acute lymphoblastic leukemias with t(5;14)(q34;q11).  |  Hansen-Hagge, TE., et al. 2002. Leukemia. 16: 2205-12. PMID: 12399963
3. Chromosomal excision of TCRdelta chain genes is dispensable for alphabeta T cell lineage commitment.  |  Khor, B., et al. 2005. Int Immunol. 17: 225-32. PMID: 15642954
4. The differentiation of human pro-thymocytes along the TCR-alpha/beta pathway in vitro is accompanied by the site-specific deletion of the TCR-delta locus.  |  de Villartay, JP., et al. 1991. Int Immunol. 3: 1301-5. PMID: 1838004
5. Recombination signal sequence-associated restriction on TCRdelta gene rearrangement affects the development of tissue-specific gammadelta T cells.  |  Uche, UN., et al. 2009. J Immunol. 183: 4931-9. PMID: 19801518
6. Acute T-lymphocytic leukemia with Ph1 and 5q-chromosome abnormalities and rearrangements of bcr and TCR-delta genes.  |  Takechi, M., et al. 1990. Leuk Res. 14: 885-93. PMID: 2147972
7. A second TCRδ locus in Galliformes uses antibody-like V domains: insight into the evolution of TCRδ and TCRμ genes in tetrapods.  |  Parra, ZE., et al. 2012. J Immunol. 188: 3912-9. PMID: 22407916
8. Tcrδ translocations that delete the Bcl11b haploinsufficient tumor suppressor gene promote atm-deficient T cell acute lymphoblastic leukemia.  |  Ehrlich, LA., et al. 2014. Cell Cycle. 13: 3076-82. PMID: 25486566
9. Acute myeloid and T-cell acute lymphoblastic leukaemia with aberrant antigen expression exhibit similar TCRdelta gene rearrangements.  |  Schmidt, CA., et al. 1996. Br J Haematol. 92: 929-36. PMID: 8616087
10. Human T cell leukemias with continuous V(D)J recombinase activity for TCR-delta gene deletion.  |  Breit, TM., et al. 1997. J Immunol. 159: 4341-9. PMID: 9379030

The preferred TCR δ antibody is TCR δ Antibody (H-41): sc-100289.