TCR γ/δ Antibody (5K24): sc-73123
- TCR γ/δ Antibody (5K24) is a Armenian hamster monoclonal IgG provided at 200 µg/ml
- raised against TCR γ/δ of mouse origin
- recommended for detection of TCR γ and TCR δ of mouse origin by IF and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TCR γ/δ Antibody (5K24). This work is in progress.
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TCR γ/δ Antibody (5K24) is a hamster monoclonal IgG antibody that detects TCR γ/δ in mouse samples through immunofluorescence (IF) and flow cytometry (FCM) applications. TCR γ/δ is a crucial component of the T cell antigen receptor complex, primarily expressed on a subset of T cells that play a significant role in the immune response, particularly in recognizing non-peptide antigens and responding to stress signals. Unlike the more common TCR α/β, TCR γ/δ T cells are known for their ability to respond rapidly to infections and tumors, making these cells vital for early immune defense. TCR γ/δ T cells are predominantly located in epithelial tissues, such as the skin and gut, where these cells contribute to the first line of defense against pathogens. The unique localization of TCR γ/δ T cells allows rapid response to local infections and maintains tissue homeostasis, highlighting TCR γ/δ′s importance in both innate and adaptive immunity. Anti-TCR γ/δ antibody (5K24) is an essential tool for researchers studying the dynamics of T cell responses and the role of these unique T cell subsets in various immunological contexts.
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TCR γ/δ Antibody (5K24) References:
- Lipopolysaccharide aggravates cerebral pathology in B10.PL-derived CD1-/-, beta2m-/-, TCRalpha-/-, and TCRdelta-/- knockout mice. | Sura, P., et al. 2006. Folia Biol (Krakow). 54: 139-44. PMID: 17220009
- RUNX1-dependent RAG1 deposition instigates human TCR-δ locus rearrangement. | Cieslak, A., et al. 2014. J Exp Med. 211: 1821-32. PMID: 25135298
- Chromatin Dynamics and the Development of the TCRα and TCRδ Repertoires. | Carico, Z. and Krangel, MS. 2015. Adv Immunol. 128: 307-61. PMID: 26477370
- mTORC1 in Thymic Epithelial Cells Is Critical for Thymopoiesis, T-Cell Generation, and Temporal Control of γδT17 Development and TCRγ/δ Recombination. | Wang, HX., et al. 2016. PLoS Biol. 14: e1002370. PMID: 26889835
- Durable Expansion of TCR-δ Meta-Clonotypes After BCG Revaccination in Humans. | James, CA., et al. 2022. Front Immunol. 13: 834757. PMID: 35432299
- Interleukin-7 receptor signaling is crucial for enhancer-dependent TCRδ germline transcription mediated through STAT5 recruitment. | Rodríguez-Caparrós, A., et al. 2022. Front Immunol. 13: 943510. PMID: 36059467
- Complete TCR-delta rearrangements and partial (D-J) recombination of the TCR-beta locus in CD34+7+ precursors from human cord blood. | Ktorza, S., et al. 1996. J Immunol. 156: 4120-7. PMID: 8666778
- The TCR-delta repertoire in human intestine undergoes characteristic changes during fetal to adult development. | Holtmeier, W., et al. 1997. J Immunol. 158: 5632-41. PMID: 9190911
- TCR-delta gene rearrangement and selection during fetal thymocyte development. | Wilbert, OM., et al. 1997. J Immunol. 159: 3338-46. PMID: 9317132
- The homogeneity of the TCRdelta repertoire expressed by the Thy-1dull gammadelta T cell population is due to cellular selection. | Azuara, V., et al. 1998. Eur J Immunol. 28: 3456-67. PMID: 9842888
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TCR γ/δ Antibody (5K24) | sc-73123 | 200 µg/ml | $322.00 |