TCPOBOP (CAS 76150-91-9)
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TCPOBOP is the most potent known member of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents. TCPOBOP, short for 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, is a synthetic chemical compound that is used as a selective agonist of the constitutive androstane receptor (CAR). It is employed in laboratory research studies to investigate the role and function of CAR in various biological processes. TCPOBOP induces activity of ER1 cytochrome P450 isozymes, NADPH-cytochrome c reductase, microsomal epoxide hydrolase and glutathione S transferase. TCPOBOP acts as a tumor promoter of murine hepatocarcinogenesis and activates orphan nuclear receptors mCAR (mouse Constitutive Androstane Receptor) and hPXR(human Pregnane X Receptor), but has little or no activity on hCAR and mPXR. Additionally, TCPOBOP also suppresses the multidrug resistance gene expression in mouse liver cells.
TCPOBOP (CAS 76150-91-9) References
- Aging does not reduce the hepatocyte proliferative response of mice to the primary mitogen TCPOBOP. | Ledda-Columbano, GM., et al. 2004. Hepatology. 40: 981-8. PMID: 15382178
- Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. | Baskin-Bey, ES., et al. 2006. Hepatology. 44: 252-62. PMID: 16799968
- Constitutive androstane receptor agonist, TCPOBOP, attenuates steatohepatitis in the methionine choline-deficient diet-fed mouse. | Baskin-Bey, ES., et al. 2007. World J Gastroenterol. 13: 5635-41. PMID: 17948939
- Identification of Candidate Target Cyp Genes for microRNAs Whose Expression Is Altered by PCN and TCPOBOP, Representative Ligands of PXR and CAR. | Moriya, N., et al. 2016. Biol Pharm Bull. 39: 1381-6. PMID: 27237601
- The CAR agonist TCPOBOP inhibits lipogenesis and promotes fibrosis in the mammary gland of adolescent female mice. | Xu, P., et al. 2018. Toxicol Lett. 290: 29-35. PMID: 29550551
- Impact of CAR Agonist Ligand TCPOBOP on Mouse Liver Chromatin Accessibility. | Lodato, NJ., et al. 2018. Toxicol Sci. 164: 115-128. PMID: 29617930
- TCPOBOP-Induced Hepatomegaly and Hepatocyte Proliferation are Attenuated by Combined Disruption of MET and EGFR Signaling. | Bhushan, B., et al. 2019. Hepatology. 69: 1702-1718. PMID: 29888801
- Development of organoid-based drug metabolism model. | Park, E., et al. 2019. Toxicol Appl Pharmacol. 385: 114790. PMID: 31678242
- Constitutive androstane receptor induced-hepatomegaly and liver regeneration is partially via yes-associated protein activation. | Gao, Y., et al. 2021. Acta Pharm Sin B. 11: 727-737. PMID: 33777678
- Off-target lipid metabolism disruption by the mouse constitutive androstane receptor ligand TCPOBOP in humanized mice. | Skoda, J., et al. 2022. Biochem Pharmacol. 197: 114905. PMID: 34971590
- Constitutive Androstane Receptor Agonist, TCPOBOP: Maternal Exposure Impairs the Growth and Development of Female Offspring in Mice. | Pan, S., et al. 2023. Int J Mol Sci. 24: PMID: 36768963
- Dose-response relationships for the induction of P450 2B by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzne (TCPOBOP) in rat and cultured rat hepatocytes. | Nims, RW., et al. 1993. Xenobiotica. 23: 1411-26. PMID: 7510916
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TCPOBOP, 25 mg | sc-203291 | 25 mg | $209.00 |