TCP-10 Antibody (E-6): sc-398772

TCP-10 Antibody (E-6) is a mouse monoclonal IgG2b kappa light chain antibody that detects TCP-10 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TCP-10 (E-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TCP-10, also known as t-complex 10 homolog or TCP10A, consists of 353 amino acids and belongs to the TCP10 family, which plays a crucial role in cellular processes such as protein folding and stress response. TCP-10 is primarily located in the cytoplasm and is involved in the regulation of chaperone activity, which is essential for maintaining cellular homeostasis and preventing the aggregation of misfolded proteins. Proper functioning of TCP-10 is vital, as disruptions in TCP-10 activity can lead to various diseases, including neurodegenerative disorders and certain cancers. The gene encoding TCP-10 is situated on human chromosome 6q27, a region significant not only for high gene density but also for association with several genetic disorders, including early onset intestinal cancer and bipolar disorder. Anti-TCP-10 antibody (E-6) enables valuable insights into TCP-10′s role in health and disease, making TCP-10 (E-6) monoclonal antibody an essential tool for studies focused on cellular stress responses and related pathologies.

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TCP-10 Antibody (E-6) References:

1. The DNA sequence and analysis of human chromosome 6.  |  Mungall, AJ., et al. 2003. Nature. 425: 805-11. PMID: 14574404
2. A stop codon mutation in COL11A2 induces exon skipping and leads to non-ocular Stickler syndrome.  |  Vuoristo, MM., et al. 2004. Am J Med Genet A. 130A: 160-4. PMID: 15372529
3. Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q.  |  McQueen, MB., et al. 2005. Am J Hum Genet. 77: 582-95. PMID: 16175504
4. Iron overload syndromes and the liver.  |  Batts, KP. 2007. Mod Pathol. 20 Suppl 1: S31-9. PMID: 17486050
5. The HLA-A1-B8 haplotype hitchhiking with the hemochromatosis mutation: does it affect the phenotype?  |  Olsson, KS., et al. 2007. Eur J Haematol. 79: 429-34. PMID: 17924859
6. Modulation of parkin gene expression in noradrenergic neuronal cells.  |  Park, E., et al. 2007. Int J Dev Neurosci. 25: 491-7. PMID: 17976945
7. A disease state mutation unfolds the parkin ubiquitin-like domain.  |  Safadi, SS. and Shaw, GS. 2007. Biochemistry. 46: 14162-9. PMID: 18004887
8. Recurrent deletions at 6q in early age of onset non-HNPCC- and non-FAP-associated intestinal carcinomas. Evidence for a novel cancer susceptibility locus at 6q14-q22.  |  Bläker, H., et al. 2008. Genes Chromosomes Cancer. 47: 159-64. PMID: 18008368
9. Characterization of a Novel DNA Motif in the Tctex1 and TCP10 Gene Complexes and its Prevalence in the Mouse Genome.  |  Doukeris, CE. and Planchart, A. 2007. Adv Biol Res (Rennes). 1: 1-16. PMID: 20514145

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TCP-10 Antibody (E-6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-TCP-10 Antibody (E-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TCP-10 Antibody (E-6) Specifications

Alternate Product Name: TCP-10

Product Clone Name: E-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 258-282

Epitope Target: TCP-10

Epitope Species: human

Product Reactivity/Detection: TCP-10

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for TCP-10 Antibody (E-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin