TCP-1 η Antibody (H-4): sc-390492

TCP-1 η Antibody (H-4) is a mouse monoclonal IgG2a antibody that detects TCP-1 η in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TCP-1 η is a crucial subunit of the chaperonin containing TCP-1 (CCT) complex, which is essential for the proper folding of cytosolic proteins, particularly actins and tubulins. TCP-1 η is located in the eukaryotic cytosol, where TCP-1 η plays a vital role in maintaining cellular function by ensuring critical proteins achieve their correct three-dimensional structures. The proper folding of actins and tubulins is important for various cellular processes, including cytoskeletal organization, cell motility, and intracellular transport. TCP-1 η, along with fellow subunits, contributes to the overall efficiency of the chaperonin complex, which is necessary for cellular homeostasis and response to stress. The interaction of TCP-1 η with other subunits of the CCT complex highlights anti-TCP-1 η antibody (H-4) as an invaluable tool for researchers studying protein dynamics and cellular function in human tissues.

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TCP-1 η Antibody (H-4) References:

1. Discovery and scoring of protein interaction subnetworks discriminative of late stage human colon cancer.  |  Nibbe, RK., et al. 2009. Mol Cell Proteomics. 8: 827-45. PMID: 19098285
2. Effect of Inulin on Proteome Changes Induced by Pathogenic Lipopolysaccharide in Human Colon.  |  Guarino, MP., et al. 2017. PLoS One. 12: e0169481. PMID: 28068390
3. Overexpression of chaperonin containing T-complex polypeptide subunit zeta 2 (CCT6b) suppresses the functions of active fibroblasts in a rat model of joint contracture.  |  Yi, X., et al. 2019. J Orthop Surg Res. 14: 125. PMID: 31072365
4. An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity.  |  Jin, M., et al. 2019. Proc Natl Acad Sci U S A. 116: 19513-19522. PMID: 31492816
5. The TCP1 ring complex is associated with malignancy and poor prognosis in hepatocellular carcinoma.  |  Yao, L., et al. 2019. Int J Clin Exp Pathol. 12: 3329-3343. PMID: 31934176
6. State-dependent sequential allostery exhibited by chaperonin TRiC/CCT revealed by network analysis of Cryo-EM maps.  |  Zhang, Y., et al. 2021. Prog Biophys Mol Biol. 160: 104-120. PMID: 32866476
7. Systematic Characterization of Expression Profiles and Prognostic Values of the Eight Subunits of the Chaperonin TRiC in Breast Cancer.  |  Xu, WX., et al. 2021. Front Genet. 12: 637887. PMID: 33815471
8. T-complex protein 1 subunit zeta-2 (CCT6B) deficiency induces murine teratospermia.  |  Yang, P., et al. 2021. PeerJ. 9: e11545. PMID: 34141486
9. Proteomic identification of arginine-methylated proteins in colon cancer cells and comparison of messenger RNA expression between colorectal cancer and adjacent normal tissues.  |  Lim, Y., et al. 2022. Ann Coloproctol. 38: 60-68. PMID: 35081685
10. Cell cycle protein BORA is associated with colorectal cancer progression by AURORA-PLK1 cascades: a bioinformatics analysis.  |  Mahajan, M., et al. 2023. J Cell Commun Signal. 17: 773-791. PMID: 36538275

The preferred TCP-1 η antibody is TCP-1 η Antibody (A-8): sc-271951.