TCP-1 η Antibody (C-9): sc-374617

TCP-1 η Antibody (C-9) is a mouse monoclonal IgG2a antibody that detects TCP-1 η in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TCP-1 η is a crucial subunit of the chaperonin containing TCP-1 (CCT) complex, which is essential for the proper folding of cytosolic proteins, particularly actins and tubulins. TCP-1 η plays a significant role in maintaining cellular function by ensuring vital cytoskeletal components are correctly folded and assembled, which is critical for various cellular processes, including cell shape, motility, and division. The CCT complex, composed of eight distinct subunits, including TCP-1 η, operates in a highly regulated manner to facilitate the folding of substrates, thereby preventing misfolding and aggregation that could lead to cellular dysfunction. TCP-1 η has been shown to interact with other subunits of the CCT complex, highlighting TCP-1 η′s importance in the overall chaperoning process. The ability of TCP-1 η to assist in protein folding underlines TCP-1 η′s significance in cellular homeostasis and potential implications in diseases associated with protein misfolding.

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TCP-1 η Antibody (C-9) References:

1. Intron sequences from the CCT7 gene exhibit diverse evolutionary histories among the four lineages within the Babesia microti-group, a genetically related species complex that includes human pathogens.  |  Fujisawa, K., et al. 2011. Jpn J Infect Dis. 64: 403-10. PMID: 21937822
2. G-protein signaling modulator-3 regulates heterotrimeric G-protein dynamics through dual association with Gβ and Gαi protein subunits.  |  Giguère, PM., et al. 2012. J Biol Chem. 287: 4863-74. PMID: 22167191
3. Dysfunctional nitric oxide signalling increases risk of myocardial infarction.  |  Erdmann, J., et al. 2013. Nature. 504: 432-6. PMID: 24213632
4. Lecithin Prevents Cortical Cytoskeleton Reorganization in Rat Soleus Muscle Fibers under Short-Term Gravitational Disuse.  |  Ogneva, IV. and Biryukov, NS. 2016. PLoS One. 11: e0153650. PMID: 27073851
5. Regulation of GPCR expression through an interaction with CCT7, a subunit of the CCT/TRiC complex.  |  Génier, S., et al. 2016. Mol Biol Cell. 27: 3800-3812. PMID: 27708139
6. Extracellular Vesicles from Neurosurgical Aspirates Identifies Chaperonin Containing TCP1 Subunit 6A as a Potential Glioblastoma Biomarker with Prognostic Significance.  |  Hallal, S., et al. 2019. Proteomics. 19: e1800157. PMID: 30451371
7. Urinary TCP1-eta: A Cortical Damage Marker for the Pathophysiological Diagnosis and Prognosis of Acute Kidney Injury.  |  Sancho-Martínez, SM., et al. 2020. Toxicol Sci. 174: 3-15. PMID: 31825490
8. Combined use of GM2AP and TCP1-eta urinary levels predicts recovery from intrinsic acute kidney injury.  |  Blanco-Gozalo, V., et al. 2020. Sci Rep. 10: 11599. PMID: 32665654
9. Clinical Significance, Cellular Function, and Potential Molecular Pathways of CCT7 in Endometrial Cancer.  |  Wang, L., et al. 2020. Front Oncol. 10: 1468. PMID: 32983981
10. Prognostic Power of a Chaperonin Containing TCP-1 Subunit Genes Panel for Hepatocellular Carcinoma.  |  Li, W., et al. 2021. Front Genet. 12: 668871. PMID: 33897772

The preferred TCP-1 η antibody is TCP-1 η Antibody (A-8): sc-271951.