TCP-1 α Antibody (84a): sc-53453
- TCP-1 α Antibody (84a) is a rat monoclonal IgG2a provided at 200 µg/ml
- raised against the C-terminal half of TCP of murine origin
- recommended for detection of TCP-1α of mouse, rat, human and hamster origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TCP-1 α Antibody (84a). This work is in progress.
TCP-1 α Antibody (84a) is a rat monoclonal IgG2a antibody that detects TCP-1 in mouse, rat, human, and hamster samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). TCP-1, or t complex polypeptide 1, is a crucial subunit of the chaperonin containing TCP-1 (CCT) complex, which is essential for the proper folding of cytosolic proteins, particularly actins and tubulins. The CCT complex is composed of eight distinct subunits, each encoded by different genes, and plays a vital role in maintaining cellular function by ensuring that proteins achieve their correct conformation. TCP-1 involvement in various cellular processes, including cell division and cytoskeletal organization, is critical for maintaining structural integrity and functionality of cells. TCP-1 has been linked to developmental processes, as its absence can lead to embryonic lethality in model organisms. TCP-1′s ability to interact with other proteins and assist in their folding highlights its significance in cellular homeostasis and the potential consequences of its dysfunction, which can lead to various diseases. Anti-TCP-1 antibody (84a) is an invaluable tool for researchers studying the dynamics of protein folding and the role of molecular chaperones in health and disease.
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TCP-1 α Antibody (84a) References:
- N-terminal domain-mediated homodimerization is required for photoreceptor activity of Arabidopsis CRYPTOCHROME 1. | Sang, Y., et al. 2005. Plant Cell. 17: 1569-84. PMID: 15805487
- CTP:phosphocholine cytidylyltransferase: Function, regulation, and structure of an amphitropic enzyme required for membrane biogenesis. | Cornell, RB. and Ridgway, ND. 2015. Prog Lipid Res. 59: 147-71. PMID: 26165797
- mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretion. | Quinn, WJ., et al. 2017. J Clin Invest. 127: 4207-4215. PMID: 29035283
- How CCTα puts a leash on phospholipid synthesis. | Ridgway, ND. 2018. J Biol Chem. 293: 7085-7086. PMID: 29728535
- CCTα Commands Phospholipid Homeostasis from the Nucleus. | Cornell, R. and Antonny, B. 2018. Dev Cell. 45: 419-420. PMID: 29787704
- State-dependent sequential allostery exhibited by chaperonin TRiC/CCT revealed by network analysis of Cryo-EM maps. | Zhang, Y., et al. 2021. Prog Biophys Mol Biol. 160: 104-120. PMID: 32866476
- Activation of Liver mTORC1 Protects Against NASH via Dual Regulation of VLDL-TAG Secretion and De Novo Lipogenesis. | Uehara, K., et al. 2022. Cell Mol Gastroenterol Hepatol. 13: 1625-1647. PMID: 35240344
- Differential contributions of phosphotransferases CEPT1 and CHPT1 to phosphatidylcholine homeostasis and lipid droplet biogenesis. | Dorighello, G., et al. 2023. J Biol Chem. 299: 104578. PMID: 36871755
- Saccharomyces cerevisiae survival against heat stress entails a communication between CCT and cell wall integrity pathway. | Dube, A., et al. 2023. Biol Futur. 74: 519-527. PMID: 37964139
- Lipid- and phospho-regulation of CTP:Phosphocholine Cytidylyltransferase α association with nuclear lipid droplets. | Foster, J., et al. 2024. Mol Biol Cell. 35: ar33. PMID: 38170618
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TCP-1 α Antibody (84a) | sc-53453 | 200 µg/ml | $322.00 |