TCP-1 α Antibody (23c): sc-53452
- TCP-1 α Antibody (23c) is a rat monoclonal IgG2c provided at 200 µg/ml
- raised against the C-terminal half of TCP of murine origin
- recommended for detection of TCP-1α of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TCP-1 α Antibody (23c). This work is in progress.
TCP-1 α Antibody (23c) is a rat monoclonal IgG2c antibody that detects TCP-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TCP-1, or t complex polypeptide 1, is a crucial subunit of the chaperonin containing TCP-1 (CCT) complex, which is essential for the proper folding of cytosolic proteins, particularly actins and tubulins. The CCT complex is composed of eight distinct subunits, each encoded by different genes, and plays a vital role in maintaining cellular homeostasis by ensuring that proteins achieve their functional conformations. TCP-1 is involved in various cellular processes, including cell division and cytoskeletal organization, which are critical for normal development and function. TCP-1 has been linked to specific phenotypes in model organisms, such as the tail-less and embryonic lethal phenotypes observed in mice, highlighting its significance in developmental biology. TCP-1′s ability to interact with other proteins within the CCT complex further emphasizes its role as a molecular chaperone, making anti-TCP-1 antibody (23c) an invaluable tool for researchers studying protein folding and related cellular mechanisms.
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TCP-1 α Antibody (23c) References:
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- Molecular mechanisms involved in farnesol-induced apoptosis. | Joo, JH. and Jetten, AM. 2010. Cancer Lett. 287: 123-35. PMID: 19520495
- The structure and evolution of eukaryotic chaperonin-containing TCP-1 and its mechanism that folds actin into a protein spring. | Willison, KR. 2018. Biochem J. 475: 3009-3034. PMID: 30291170
- Genetic diseases of the Kennedy pathways for membrane synthesis. | Tavasoli, M., et al. 2020. J Biol Chem. 295: 17877-17886. PMID: 33454021
- Chaperonins in cancer: Expression, function, and migration in extracellular vesicles. | Macario, AJL. and Conway de Macario, E. 2022. Semin Cancer Biol. 86: 26-35. PMID: 34087417
- Cultural competency education in the medical curriculum to overcome health care disparities. | Lakra, R., et al. 2023. Proc (Bayl Univ Med Cent). 36: 616-619. PMID: 37614855
- STYXL1 regulates CCT complex assembly and flagellar tubulin folding in sperm formation. | Chen, Y., et al. 2024. Nat Commun. 15: 44. PMID: 38168070
- AKT2S128/CCTαS315/319/323-positive cancer-associated fibroblasts (CAFs) mediate focal adhesion kinase (FAK) inhibitors resistance via secreting phosphatidylcholines (PCs). | Chen, J., et al. 2024. Signal Transduct Target Ther. 9: 21. PMID: 38280862
- BDNF and TRiC-inspired reagent rescue cortical synaptic deficits in a mouse model of Huntington's disease. | Gu, Y., et al. 2024. Neurobiol Dis. 195: 106502. PMID: 38608784
- Phosphatidylserine enrichment in the nuclear membrane regulates key enzymes of phosphatidylcholine synthesis. | Niu, Y., et al. 2024. EMBO J. 43: 3414-3449. PMID: 38918635
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TCP-1 α Antibody (23c) | sc-53452 | 200 µg/ml | $316.00 |