TCEP, Hydrochloride CAS: 51805-45-9
MF: C9H15O6P•HCl
MW: 286.65
A water soluble, non-thiol, strong reducing agent shown to cleave disulfide bonds.

TCEP, Hydrochloride (CAS 51805-45-9)

TCEP, Hydrochloride | CAS 51805-45-9 is rated 5.0 out of 5 by 2.
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Synonym: tris(2-Carboxyethyl)phosphine, HCl
Application: A water soluble, non-thiol, strong reducing agent shown to cleave disulfide bonds
CAS Number: 51805-45-9
Purity: ≥98%
Molecular Weight: 286.65
Molecular Formula: C9H15O6P•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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TCEP Hydrochloride is a water soluble, non-thiol, strong reducing agent shown to cleave disulfide bonds. Reports indicate that TCEP Hydrochloride can rapidly reduce stable alkyl disulfides, including DTT. TCEP Hydrochloride has been observed to reduce DHA in a solution of EDTA and metaphosphoric acid, and used to conduct proteolysis and Hydrogen/Deuterium exchange. Binding studies demonstrate that TCEP Hydrochloride does not bind Hg2+, and its binding efficacy to NF-κB-DNA has been tested in vitro.


References

1. Han, J.C. and Han, G.Y. 1994. Anal. Biochem. 220: 5-10. PMID: 7978256
2. Pomroy, N.C., et al. 1998. Biochem. Biophys. Res. Commun. 245: 618-621. PMID: 9571204
3. Lykkesfeldt, J. 2000. Anal. Biochem. 282: 89-93. PMID: 10860503
4. Dieguez-Acuña, F.J. and Woods, J.S. 2000. Toxicol In Vitro. 14: 7-16. PMID: 10699356
5. Zhang, H.M., et al. 2010. Anal. Chem. 82: 1450-1454. PMID: 20099838
6. Sato, Y., et al. 2010. Biol. Pharm. Bull. 33: 364-369. PMID: 20190394

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in water (5 mg/ml), and methanol.
Storage :
Store at 4° C
Melting Point :
175-179° C
Boiling Point :
519.4° C at 760 mmHg (Predicted)
Density :
1.04 g/cm3 at 25° C
Refractive Index :
n20D 1.37
Optical Activity :
α20/D 1.37°
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
PubChem CID :
2734570
Merck Index :
14: 9085
MDL Number :
MFCD00145469
Beilstein Registry :
3724376
SMILES :
C(CP(CCC(=O)O)CCC(=O)O)C(=O)O.Cl

Download SDS (MSDS)

Certificate of Analysis

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TCEP, Hydrochloride  Product Citations

See how others have used TCEP, Hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 8 of 8 total

PMID: # 20415433  Linn, KM. et al. 2010. Biochemistry. 49: 4450-4456.

PMID: # 18835446  Lyubchenko, YL. et al. 2009. Methods. 47: 206-213.

PMID: # 19223330  He, Y. et al. 2009. Nucleic Acids Res. 37: 2142-2152.

PMID: # 17908300  Tyagi, R. et al. 2007. BMC Struct. Biol. 7: -.

PMID: # 17133367  Flory, MR. et al. 2006. Proteomics. 6: 6146-6157.

PMID: # 16198641  Berthold, CL. et al. 2006. Biochim. Biophys. Acta. 1764: 122-128.

PMID: # 12183225  Hackbarth, CJ. et al. 2002. Antimicrob. Agents Chemother. 46: 2752-2764.

PMID: # 9874226  Oudot, C. et al. 1998. Eur. J. Biochem. 258: 579-585.

Citations 1 to 8 of 8 total
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Rated 5 out of 5 by from Recommended I brought it a month ago. I have used it and happy with the product.
Date published: 2020-03-14
Rated 5 out of 5 by from Linn et al Linn et al. (PubMed ID 20415433 ) used TCEP, Hydrochloride to access Cys residues at the N-terminus of the C peptide by cleaving the disulfide bond between the C and the TST peptide. -SCBT Publication Review
Date published: 2015-03-05
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