TC 2559 difumarate CAS: 212332-35-9
MF: C12H18N2O 2C4H4O4
MW: 438.43
A partial agonist for AChR α4β2.

TC 2559 difumarate (CAS 212332-35-9)

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Alternate Names: 4-(5-ethoxy-3-pyridinyl)-N-methyl-(3E)-3-buten-1-amine difumarate
Application: TC 2559 difumarate is a partial agonist for AChR α4β2
CAS Number: 212332-35-9
Purity: >98%
Molecular Weight: 438.43
Molecular Formula: C12H18N2O 2C4H4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

TC 2559 difumarate is a subtype-selective partial agonist for AChR α4β2 (EC50 values are 0.18, 12.5, 14.0, > 30, > 100 and > 100 μM for α4β2, α4β4, α2β4, α3β4, α3β2 and α7 receptor subtypes, respectively). It displays selectivity for (α4)2(β2)3 receptor stoichiometry and enhanced CNS-PNS slectivity ratio.


References

1. Bencherif, M., et al. 2000. Eur. J. Pharmacol. 409 45-55.
2. Chen, Y., et al. 2003. Neuropharmacology. 45: 334-344
3. Zwart, R., et al. 2006. Eur. J. Pharmacol. 539: 10-17.

Physical State :
Solid
Solubility :
Soluble in water (100 mM).
Storage :
Desiccate at room temperature
Boiling Point :
753.7° C at 760 mmHg (Predicted)
Refractive Index :
n20D ~1.54 (Predicted)
IC50 :
AChRα4β2: EC5050 = 0.18 µM; AChRα4β4: EC5050 = 12.5 µM; AChRα2β4: EC5050 = 14.0 µM; AChRα3β4: EC5050 = >30 µM; AChRα3β2: EC5050 = >100 µM; AChRα7: EC5050 = >100 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
56972184
SMILES :
CCOC1=CN=CC(=C1)/C=C/CCNC.C(=C/C(=O)O)\\C(=O)O.C(=C/C(=O)O)\\C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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