Molecular structure of TC 1698 dihydrochloride, CAS Number: 700834-58-8
TC 1698 dihydrochloride (CAS 700834-58-8)
Alternate Names:
2-(3-Pyridinyl)-1-azabicyclo[3.2.2]nonane dihydrochloride
Application:
TC 1698 dihydrochloride is a selective AChR α7 agonist
CAS Number:
700834-58-8
Molecular Weight:
275.22
Molecular Formula:
C13H18N2•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Selective nicotinic α7 receptor agonist (EC50 = 440 nM). Displays a weak partial agonist/antagonist activity at β-subunit-containing receptors. Also neuroprotective.
TC 1698 dihydrochloride (CAS 700834-58-8) References
- The neuroprotective effect of 2-(3-pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel alpha7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase. | Marrero, MB., et al. 2004. J Pharmacol Exp Ther. 309: 16-27. PMID: 14722323
- Molecular dissection of tropisetron, an alpha7 nicotinic acetylcholine receptor-selective partial agonist. | Papke, RL., et al. 2005. Neurosci Lett. 378: 140-4. PMID: 15781147
- Rhesus monkey alpha7 nicotinic acetylcholine receptors: comparisons to human alpha7 receptors expressed in Xenopus oocytes. | Papke, RL., et al. 2005. Eur J Pharmacol. 524: 11-8. PMID: 16266703
- Selective alpha7 nicotinic acetylcholine receptor ligands. | Mazurov, A., et al. 2006. Curr Med Chem. 13: 1567-84. PMID: 16787204
- Synthesis, nicotinic acetylcholine receptor binding, antinociceptive and seizure properties of methyllycaconitine analogs. | Ivy Carroll, F., et al. 2007. Bioorg Med Chem. 15: 678-85. PMID: 17098430
- Reversal of agonist selectivity by mutations of conserved amino acids in the binding site of nicotinic acetylcholine receptors. | Horenstein, NA., et al. 2007. J Biol Chem. 282: 5899-909. PMID: 17189260
- Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptor. | Hibbs, RE., et al. 2009. EMBO J. 28: 3040-51. PMID: 19696737
- Discrimination of agonists versus antagonists of nicotinic ligands based on docking onto AChBP structures. | Taly, A., et al. 2011. J Mol Graph Model. 30: 100-9. PMID: 21764343
- Unique pharmacology of heteromeric α7β2 nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes. | Zwart, R., et al. 2014. Eur J Pharmacol. 726: 77-86. PMID: 24485886
- Alpha7 nicotinic receptors as therapeutic targets for Parkinson's disease. | Quik, M., et al. 2015. Biochem Pharmacol. 97: 399-407. PMID: 26093062
- Heteromeric α7β2 Nicotinic Acetylcholine Receptors in the Brain. | Wu, J., et al. 2016. Trends Pharmacol Sci. 37: 562-574. PMID: 27179601
- Dual Nicotinic Acetylcholine Receptor α4β2 Antagonists/α7 Agonists: Synthesis, Docking Studies, and Pharmacological Evaluation of Tetrahydroisoquinolines and Tetrahydroisoquinolinium Salts. | Crestey, F., et al. 2018. J Med Chem. 61: 1719-1729. PMID: 29384668
- Machine Learning Neuroprotective Strategy Reveals a Unique Set of Parkinson Therapeutic Nicotine Analogs. | Rojas-Rodríguez, F., et al. 2020. Open Bioinforma J. 13: 1-14. PMID: 33927788
- Insights Into the Differential Desensitization of α4β2 Nicotinic Acetylcholine Receptor Isoforms Obtained With Positive Allosteric Modulation of Mutant Receptors. | Papke, RL. and Stokes, C. 2023. Mol Pharmacol. 103: 63-76. PMID: 36414373
Activator of:
AChR α 7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TC 1698 dihydrochloride, 10 mg | sc-204324 | 10 mg | $155.00 | |||
TC 1698 dihydrochloride, 50 mg | sc-204324A | 50 mg | $620.00 |