TC 1698 dihydrochloride is a selective AChR α7 agonist (EC50 = 440 nM). It displays a weak partial agonist/antagonist activity at β-subunit-containing receptors. TC 1698 dihydrochloride is also a neuroprotective.
Marrero et al (2004) The neuroprotective effect of 2-(3-Pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel a7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase. J.Pharmacol.Exp.Ther. 309 16. Papke et al (2005) Rhesus monkey a7 nicotinic acetylcholine receptors: comparisons to human a7 receptors expressed in Xenopus oocytes. Eur.J.Pharmacol. 524 11.
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