TC 1698 dihydrochloride CAS: 700834-58-8
MF: C13H18N2•2HCl
MW: 275.22
A selective AChR α7 agonist.

TC 1698 dihydrochloride (CAS 700834-58-8)

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Alternate Names: 2-(3-Pyridinyl)-1-azabicyclo[3.2.2]nonane dihydrochloride
Application: TC 1698 dihydrochloride is a selective AChR α7 agonist
CAS Number: 700834-58-8
Molecular Weight: 275.22
Molecular Formula: C13H18N22HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

TC 1698 dihydrochloride is a selective AChR α7 agonist (EC50 = 440 nM). It displays a weak partial agonist/antagonist activity at β-subunit-containing receptors. TC 1698 dihydrochloride is also a neuroprotective.


References

Marrero et al (2004) The neuroprotective effect of 2-(3-Pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel a7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase. J.Pharmacol.Exp.Ther. 309 16. Papke et al (2005) Rhesus monkey a7 nicotinic acetylcholine receptors: comparisons to human a7 receptors expressed in Xenopus oocytes. Eur.J.Pharmacol. 524 11.

Physical State :
Solid
Solubility :
Soluble in water (100 mM).
Storage :
Desiccate at room temperature
Refractive Index :
n20D 1.58 (Predicted)
IC50 :
AChRα7: EC5050 = 440 nM
Ki Data :
AChRα7: Ki= 11 nM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
21094258
SMILES :
C1CC(N2CCC1CC2)C3=CN=CC=C3.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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