Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
TBL1XR1 (transducin (beta)-like 1 X-linked receptor 1), also known as C21, DC42, IRA1 or TBLR1 (TBL1-related protein 1), is a ubiquitously expressed protein that belongs to the WD repeat EBI family of proteins. Localizing to the cytoplasm and the nucleus, TBL1XR1 contains eight WD repeats, one LisH domain and one F-box-like domain. TBL1XR1 functions as a transcriptional regulator, acting as a component of the co-repressor machinery (NCoR/SMRT complex) that is required for the activation of many transcription factors. Specifically, TBL1XR1 is essential for the recruitment of proteasome machinery and, therefore, the subsequent degradation of co-repressors upon ligand binding. The knockdown of TBL1XR1 inhibits β-catenin-mediated transcription and greatly suppresses the growth of head and neck squamous cell carcinoma cells. This suggests that TBL1XR1 may be a useful target in anti-cancer therapy.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.