TBL1XR1 Antibody (AP-86): sc-517365
- TBL1XR1 Antibody (AP-86) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against a recombinant protein corresponding to TBL1XR1 of human origin
- recommended for detection of TBL1XR1 of mouse, rat and human origin by WB, IP, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TBL1XR1 Antibody (AP-86). This work is in progress.
QUICK LINKS
TBL1XR1 Antibody (AP-86) is a mouse monoclonal IgG1 antibody that detects TBL1XR1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. TBL1XR1, also known as transducin (beta)-like 1 X-linked receptor 1, C21, DC42, IRA1, or TBLR1 (TBL1-related protein 1), is a crucial transcriptional regulator that plays a significant role in cellular processes by modulating gene expression. TBL1XR1 is primarily located in the cytoplasm and nucleus, where TBL1XR1 interacts with various transcription factors as part of the co-repressor machinery, specifically the nuclear receptor co-repressor (NCoR) and silencing mediator for retinoid and thyroid hormone receptors (SMRT) complex. The presence of eight WD repeats, one LisH domain, and one F-box-like domain in TBL1XR1 is essential for function, as these structural features facilitate protein-protein interactions and the recruitment of the proteasome machinery necessary for the degradation of co-repressors upon ligand binding. Notably, TBL1XR1 knockdown has been shown to inhibit β-catenin-mediated transcription, which significantly suppresses the growth of head and neck squamous cell carcinoma cells, highlighting TBL1XR1′s potential as a therapeutic target in cancer treatment. Anti-TBL1XR1 antibody (AP-86) is an invaluable tool for researchers investigating TBL1XR1′s role in various biological processes and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TBL1XR1 Antibody (AP-86) References:
- TBL1XR1 promotes lymphangiogenesis and lymphatic metastasis in esophageal squamous cell carcinoma. | Liu, L., et al. 2015. Gut. 64: 26-36. PMID: 24667177
- Correlations between TBL1XR1 and recurrence of colorectal cancer. | Liu, H., et al. 2017. Sci Rep. 7: 44275. PMID: 28295012
- Over-Expression of TBL1XR1 Indicates Poor Prognosis of Serous Epithelial Ovarian Cancer. | Ma, M. and Yu, N. 2017. Tohoku J Exp Med. 241: 239-247. PMID: 28344213
- De novo non-synonymous TBL1XR1 mutation alters Wnt signaling activity. | Nishi, A., et al. 2017. Sci Rep. 7: 2887. PMID: 28588275
- TBL1XR1 is involved in c-Met-mediated tumorigenesis of human nonsmall cell lung cancer. | Zhang, T., et al. 2020. Cancer Gene Ther. 27: 136-146. PMID: 31243347
- TBL1XR1 induces cell proliferation and inhibit cell apoptosis by the PI3K/AKT pathway in pancreatic ductal adenocarcinoma. | Gu, JF., et al. 2020. World J Gastroenterol. 26: 3586-3602. PMID: 32742128
- LINC01578 affects the radiation resistance of lung cancer cells through regulating microRNA-216b-5p/TBL1XR1 axis. | Wang, P., et al. 2022. Bioengineered. 13: 10721-10733. PMID: 35475502
- Exploring TBL1XR1 and NCOR1 Expression in B-cell Lymphoma Subtypes: Interaction With DNA Damage Repair Genes. | Mansoor, A., et al. 2023. Anticancer Res. 43: 4801-4807. PMID: 37909960
- The spectrum of neurological presentation in individuals affected by TBL1XR1 gene defects. | Nagy, A., et al. 2024. Orphanet J Rare Dis. 19: 79. PMID: 38378692
- Analysis of genes differentially expressed in the cortex of mice with the Tbl1xr1Y446C/Y446C variant. | Hu, Y., et al. 2024. Gene. 927: 148707. PMID: 38885822
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TBL1XR1 Antibody (AP-86) | sc-517365 | 100 µg/ml | $322.00 |