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Tazobactam sodium (CAS 89785-84-2)

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Alternate Names:
YTR-830
Application:
Tazobactam sodium is a β-lactamase inhibitor and antibacterial agent
CAS Number:
89785-84-2
Purity:
≥97%
Molecular Weight:
322.28
Molecular Formula:
C10H11N4NaO5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tazobactam sodium is a LACTB (beta-lactamase) inhibitor. As well as an inhibitor of cell wall synthesis. Tazobactam sodium, a compound widely employed in scientific research, has found utility in various applications. It has been utilized to investigate the mechanism of action of beta-lactamase inhibitors and explore the biochemical and physiological impacts of antibiotics. Moreover, Tazobactam sodium has been used in studying the effects of antibiotics on bacterial resistance.


Tazobactam sodium (CAS 89785-84-2) References

  1. [Determination of target compounds in cefoperazone sodium and tazobactam sodium for injection by capillary electrophoresis].  |  Jiang, R. and Sun, G. 2012. Se Pu. 30: 103-6. PMID: 22667102
  2. Association of Acute Kidney Injury With Concomitant Vancomycin and Piperacillin/Tazobactam Treatment Among Hospitalized Children.  |  Downes, KJ., et al. 2017. JAMA Pediatr. 171: e173219. PMID: 28973124
  3. The effects of antibiotic type and extender storage method on sperm quality and antibacterial effectiveness in fresh and cooled-stored stallion semen.  |  Hernández-Avilés, C., et al. 2018. Theriogenology. 122: 23-29. PMID: 30219312
  4. Tolerability, Safety, Pharmacokinetics and Drug Interaction of Cefotaxime Sodium-Tazobactam Sodium Injection (6:1) Following Single and Multiple Intravenous Doses in Chinese Healthy Subjects.  |  Chen, N., et al. 2020. Front Pharmacol. 11: 1033. PMID: 32733255
  5. Imipenem-resistant Pseudomonas aeruginosa treated with piperacillin/tazobactam in a patient with severe pneumonia: a case report and related literature review.  |  He, L., et al. 2021. Ann Palliat Med. 10: 810-817. PMID: 33545803
  6. Cefoperazone sodium/sulbactam sodium vs piperacillin sodium/tazobactam sodium for treatment of respiratory tract infection in elderly patients.  |  Wang, XX., et al. 2021. World J Clin Cases. 9: 8694-8701. PMID: 34734047
  7. Bloodstream infection and pneumonia caused by Chlamydia abortus infection in China: a case report.  |  Zhu, C., et al. 2022. BMC Infect Dis. 22: 181. PMID: 35197012
  8. Piperacillin/tazobactam. A review of its antibacterial activity, pharmacokinetic properties and therapeutic potential.  |  Bryson, HM. and Brogden, RN. 1994. Drugs. 47: 506-35. PMID: 7514977
  9. Compatibility of ondansetron hydrochloride and piperacillin sodium-tazobactam sodium during simulated Y-site administration.  |  Chung, KC., et al. 1995. Am J Health Syst Pharm. 52: 1554-6. PMID: 7552901
  10. Stability of piperacillin sodium-tazobactam sodium in polypropylene syringes and polyvinyl chloride minibags.  |  Moon, YS., et al. 1995. Am J Health Syst Pharm. 52: 999-1001. PMID: 7641040
  11. Stability of piperacillin sodium-tazobactam sodium and ranitidine hydrochloride in 0.9% sodium chloride injection during simulated Y-site administration.  |  Choi, JS., et al. 1994. Am J Hosp Pharm. 51: 2273-6. PMID: 7801988
  12. Stability of piperacillin sodium in the presence of tazobactam sodium in 5% dextrose and normal saline injections.  |  Mathew, M., et al. 1994. J Clin Pharm Ther. 19: 397-9. PMID: 7876373
  13. Stability of piperacillin sodium-tazobactam sodium in peritoneal dialysis solutions.  |  Park, TW., et al. 1995. Am J Health Syst Pharm. 52: 2022-4. PMID: 8528873

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tazobactam sodium, 100 mg

sc-205853
100 mg
$116.00

Tazobactam sodium, 500 mg

sc-205853A
500 mg
$354.00

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The chemical, sc-205853, is provided as a white to off-white powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-11
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Rated 5 out of 5 by from MelchersMelchers, MJ. et al. (PubMed 25824214) investigated the plasma and epithelial lining fluid pharmacokinetics (PK) of ceftolozane and tazobactam alone and in combination in mice. Thigh-infected neutropenic CD-1 mice were injected intraperitoneally with a single 0.1-ml dose containing ceftolozane, tazobactam, or both compounds. Ceftolozane was applied in 2-fold-increasing doses of 4 mg/kg of body weight to 64 mg/kg alone or in combination. There were no significant differences in the ceftolozane and tazobactam PK alone versus combined, indicating no PK interaction. The PKs were linear and dose proportional for both compounds and showed a good penetration in the epithelial lining fluid. -SCBT Publication Review
Date published: 2015-03-27
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Tazobactam sodium is rated 5.0 out of 5 by 1.
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