Molecular structure of Tazobactam, Free acid, CAS Number: 89786-04-9
Tazobactam, Free acid (CAS 89786-04-9)
See product citations (2)
Application:
Tazobactam, Free acid is a β-lactamase inhibitor
CAS Number:
89786-04-9
Molecular Weight:
300.29
Molecular Formula:
C10H12N4O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tazobactam, Free acid is a beta-lactamase inhibitor that functions by irreversibly binding to the active site of beta-lactamase enzymes, thereby preventing them from hydrolyzing beta-lactam antibiotics. This allows the antibiotics to remain active and effectively inhibit bacterial cell wall synthesis. Tazobactam, Free acid acts as a suicide substrate, forming a covalent bond with the serine residue in the active site of beta-lactamase enzymes. This interaction blocks the enzyme′s ability to break down beta-lactam antibiotics.
Tazobactam, Free acid (CAS 89786-04-9) References
- Determination of free interstitial concentrations of piperacillin-tazobactam combinations by microdialysis. | Dalla Costa, T., et al. 1998. J Antimicrob Chemother. 42: 769-78. PMID: 10052901
- Inactivation of CMY-2 beta-lactamase by tazobactam: initial mass spectroscopic characterization. | Bonomo, RA., et al. 2001. Biochim Biophys Acta. 1547: 196-205. PMID: 11410275
- Shelf lives of aseptically prepared medicines--stability of piperacillin/tazobactam in PVC and non-PVC bags. | Rigge, DC. and Jones, MF. 2005. J Pharm Biomed Anal. 39: 339-43. PMID: 16085149
- High performance liquid chromatographic determination of plasma free and total tazobactam and piperacillin. | Di Giovamberardino, G., et al. 2009. J Chromatogr B Analyt Technol Biomed Life Sci. 877: 86-8. PMID: 19058767
- Inhibition of beta-lactamases by tazobactam and in-vitro antibacterial activity of tazobactam combined with piperacillin. | Higashitani, F., et al. 1990. J Antimicrob Chemother. 25: 567-74. PMID: 2161820
- Determination of total and free ceftolozane and tazobactam in human plasma and interstitial fluid by HPLC-UV. | Kratzer, A., et al. 2019. J Pharm Biomed Anal. 163: 34-38. PMID: 30278324
- A new HPLC-MS/MS analytical method for quantification of tazobactam, piperacillin, and meropenem in human plasma. | Krnáč, D., et al. 2021. J Sep Sci. 44: 2744-2753. PMID: 33988308
- Development and validation of a liquid chromatography high-resolution mass spectrometry orbitrap method for the sensitive quantification of amoxicillin, piperacillin, tazobactam and meropenem in human faeces. | Van Vooren, S., et al. 2021. Anal Chim Acta. 1177: 338760. PMID: 34482897
- Piperacillin/tazobactam. A review of its antibacterial activity, pharmacokinetic properties and therapeutic potential. | Bryson, HM. and Brogden, RN. 1994. Drugs. 47: 506-35. PMID: 7514977
- Pharmacodynamics of piperacillin alone and in combination with tazobactam against piperacillin-resistant and -susceptible organisms in an in vitro model of infection. | Strayer, AH., et al. 1994. Antimicrob Agents Chemother. 38: 2351-6. PMID: 7840569
- Ex vivo pharmacodynamic study of piperacillin alone and in combination with tazobactam, compared with ticarcillin plus clavulanic acid. | Van der Auwera, P., et al. 1993. Antimicrob Agents Chemother. 37: 1860-8. PMID: 8239597
- The chemistry, pharmacokinetics and tissue distribution of piperacillin/tazobactam. | Sörgel, F. and Kinzig, M. 1993. J Antimicrob Chemother. 31 Suppl A: 39-60. PMID: 8383655
- Mechanism of suppression of piperacillin resistance in enterobacteria by tazobactam. | Kadima, TA. and Weiner, JH. 1997. Antimicrob Agents Chemother. 41: 2177-83. PMID: 9333044
Inhibitor of:
LACTB.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tazobactam, Free acid, 100 mg | sc-205854 | 100 mg | $62.00 | |||
Tazobactam, Free acid, 500 mg | sc-205854A | 500 mg | $201.00 | |||
Tazobactam, Free acid, 1 g | sc-205854B | 1 g | $287.00 | |||
Tazobactam, Free acid, 5 g | sc-205854C | 5 g | $624.00 |