Date published: 2025-12-18

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Tazarotene (CAS 118292-40-3)

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Application:
Tazarotene is a prodrug for tazarotenic acid with selective affinity for RARβ and RARγ
CAS Number:
118292-40-3
Purity:
≥99%
Molecular Weight:
351.46
Molecular Formula:
C21H21NO2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tazarotene is a compound that is studied primarily for its role in modulating gene expression. Within research applications that do not involve direct clinical use, tazarotene is recognized for its interaction with retinoic acid receptors, which are nuclear receptors that control the transcription of various genes. Researchers investigate how tazarotene influences cellular differentiation and proliferation, which is of interest in fields such as dermatology and oncology. It is also used in studies examining the signaling pathways involved in skin homeostasis and the molecular mechanisms that underlie various skin conditions. In the area of material science, tazarotene may be incorporated into experimental formulations to examine its stability, penetration, and release from topical delivery systems. Additionally, its effects on keratinocytes and fibroblasts are explored in vitro to better understand the compound′s influence on epidermal and dermal components.


Tazarotene (CAS 118292-40-3) References

  1. Clinical pharmacokinetics and drug metabolism of tazarotene: a novel topical treatment for acne and psoriasis.  |  Tang-Liu, DD., et al. 1999. Clin Pharmacokinet. 37: 273-87. PMID: 10554045
  2. The role of tazarotene in the treatment of psoriasis.  |  Marks, R. 1999. Br J Dermatol. 140 Suppl 54: 24-8. PMID: 10731131
  3. Tazarotene combination treatments in psoriasis.  |  Guenther, L. 2000. J Am Acad Dermatol. 43: S36-42. PMID: 10898828
  4. Tazarotene: therapeutic strategies in the treatment of psoriasis, acne and photoaging.  |  Roeder, A., et al. 2004. Skin Pharmacol Physiol. 17: 111-8. PMID: 15087589
  5. Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety.  |  Mukherjee, S., et al. 2006. Clin Interv Aging. 1: 327-48. PMID: 18046911
  6. Pharmacokinetics of tazarotene and acitretin in psoriasis.  |  Heath, MS., et al. 2018. Expert Opin Drug Metab Toxicol. 14: 919-927. PMID: 30134735
  7. Review on Characteristics and Analytical Methods of Tazarotene: An Update.  |  Gaikwad, J., et al. 2020. Crit Rev Anal Chem. 50: 90-96. PMID: 30942085
  8. Use of Topical Tazarotene for the Treatment of Acne Vulgaris in Pregnancy: A Literature Review.  |  Han, G., et al. 2020. J Clin Aesthet Dermatol. 13: E59-E65. PMID: 33133344
  9. Tazarotene gel promotes healing of deep tissue injury in mice.  |  Liu, PP., et al. 2022. Biotech Histochem. 97: 99-106. PMID: 33827340
  10. Tazarotene Lotion 0.045% for the Treatment of Acne.  |  Zip, C. 2022. Skin Therapy Lett. 27: 1-3. PMID: 35857858
  11. Tazarotene: the first receptor-selective topical retinoid for the treatment of psoriasis.  |  Chandraratna, RA. 1997. J Am Acad Dermatol. 37: S12-7. PMID: 9270551
  12. Tazarotene gel: efficacy and safety in plaque psoriasis.  |  Weinstein, GD. 1997. J Am Acad Dermatol. 37: S33-8. PMID: 9270554
  13. Tazarotene.  |  Foster, RH., et al. 1998. Drugs. 55: 705-11; discussion 712. PMID: 9585866
  14. Tazarotene in combination with phototherapy.  |  Koo, JY. 1998. J Am Acad Dermatol. 39: S144-8. PMID: 9777793

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tazarotene, 10 mg

sc-220193
10 mg
$103.00