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Taxol (CAS 33069-62-4)

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Alternate Names:
Taxol is also known as Paclitaxel.
Application:
Taxol is an antineoplastic and apoptosis inducing agent, also used to stabilize tubulin obtained from pig brain.
CAS Number:
33069-62-4
Purity:
≥99%
Molecular Weight:
853.90
Molecular Formula:
C47H51NO14
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Taxol is an alkaloid with significant interest in the field of cell biology research due to its unique mechanism of action on microtubules. It stabilizes microtubules by binding to the β-tubulin subunit, preventing their depolymerization which is essential for cell division. Consequently, it is widely used in research to study the cell cycle, particularly the dynamics of mitosis. The compound is also useful for understanding intracellular transport, as microtubules play a critical role in trafficking cellular components. In addition, its ability to induce cell cycle arrest makes Taxol a useful agent for probing the molecular pathways that control cell proliferation. Research involving Taxol has also provided insights into the development of novel strategies for inducing cell cycle arrest in rapidly dividing cells.


Taxol (CAS 33069-62-4) References

  1. Insights into the mechanism of microtubule stabilization by Taxol.  |  Xiao, H., et al. 2006. Proc Natl Acad Sci U S A. 103: 10166-10173. PMID: 16801540
  2. Phase II trial of taxol, an active drug in the treatment of metastatic breast cancer.  |  Holmes, FA., et al. 1991. J Natl Cancer Inst. 83: 1797-805. PMID: 1683908
  3. Taxol: a novel investigational antimicrotubule agent.  |  Rowinsky, EK., et al. 1990. J Natl Cancer Inst. 82: 1247-59. PMID: 1973737
  4. Taxol influences control of protofilament number at microtubule-nucleating sites in Drosophila.  |  Mogensen, MM. and Tucker, JB. 1990. J Cell Sci. 97 (Pt 1): 101-7. PMID: 1979558
  5. Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms.  |  McGuire, WP., et al. 1989. Ann Intern Med. 111: 273-9. PMID: 2569287
  6. Promotion of microtubule assembly in vitro by taxol.  |  Schiff, PB., et al. 1979. Nature. 277: 665-7. PMID: 423966
  7. Taxol stabilizes microtubules in mouse fibroblast cells.  |  Schiff, PB. and Horwitz, SB. 1980. Proc Natl Acad Sci U S A. 77: 1561-5. PMID: 6103535
  8. Inhibition of neurite initiation and growth by taxol.  |  Letourneau, PC. and Ressler, AH. 1984. J Cell Biol. 98: 1355-62. PMID: 6143759
  9. Paclitaxel (taxol) inhibits protein isoprenylation and induces apoptosis in PC-3 human prostate cancer cells.  |  Danesi, R., et al. 1995. Mol Pharmacol. 47: 1106-11. PMID: 7603448
  10. Taxol: a history of pharmaceutical development and current pharmaceutical concerns.  |  Adams, JD., et al. 1993. J Natl Cancer Inst Monogr. 141-7. PMID: 7912520
  11. Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew.  |  Stierle, A., et al. 1993. Science. 260: 214-6. PMID: 8097061
  12. Investigation of taxol as a potential radiation sensitizer.  |  Choy, H., et al. 1993. Cancer. 71: 3774-8. PMID: 8098270

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Taxol, 1 mg

sc-201439D
1 mg
$41.00

Taxol, 5 mg

sc-201439
5 mg
$74.00

Taxol, 25 mg

sc-201439A
25 mg
$221.00

Taxol, 100 mg

sc-201439E
100 mg
$247.00

Taxol, 250 mg

sc-201439B
250 mg
$738.00

Taxol, 1 g

sc-201439C
1 g
$1220.00

how do you make a stock of 10mM of paclitaxel?

Asked by: swetha
Thank you for your question. This chemical, Taxol (CAS 33069-62-4) , is soluble in ethanol (~1.5 mg/ml), DMSO (5 mg/ml), acetonitrile, methanol (50 mg/ml), chloroform, 1:10 DMSO:PBS(pH 7.2) (~0.1 mg/ml), and DMF (~5 mg/ml). Insoluble in water. This is the only information we can provide.
Answered by: Technical Support
Date published: 2017-02-03
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Rated 5 out of 5 by from Bon produitCommande effectué très simplement, produit arrivé rapidement (en stock) et qualité du produit conforme à la description.
Date published: 2021-11-29
Rated 5 out of 5 by from DanesiDanesi, R. et al. (PubMed 7603448) examined the effects of Taxol (Paclitaxel), an antineoplastic and microtubule affecting agent, in the human prostate cancer cell line PC-3. Treatment of cells with Taxol resulted in a dose-dependent inhibition of cell viability. -SCBT Publication Review
Date published: 2015-02-23
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Taxol is rated 5.0 out of 5 by 2.
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