TAUT Antibody (A-11): sc-393036
- TAUT Antibody (A-11) is a mouse monoclonal IgG1 κ TAUT antibody, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 1-52 mapping at the N-terminus of TAUT of human origin
- TAUT Antibody (A-11) is recommended for detection of TAUT of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine and canine
- Anti-TAUT Antibody (A-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TAUT Antibody (A-11). This work is in progress.
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SEE ALSO...
TAUT Antibody (A-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects TAUT protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TAUT (A-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TAUT protein, also known as the taurine transporter, is crucial for cellular homeostasis as TAUT facilitates the uptake of taurine, an important organic osmolyte that contributes to antioxidant defense and immune modulation. Located in the plasma membrane, TAUT is a multi-pass membrane protein belonging to the sodium neurotransmitter symporter family, which underscores TAUT′s role in maintaining osmotic balance and cellular integrity. Expression of TAUT is regulated by various factors, including tumor necrosis factor-alpha, which can upregulate TAUT levels, while phosphorylation at Serine 322 serves to downregulate TAUT. Notably, overexpression of TAUT has been shown to confer protection to renal cells against cisplatin-induced nephrotoxicity, highlighting TAUT′s potential therapeutic relevance in kidney injury.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TAUT Antibody (A-11) References:
- Transcriptional repression of taurine transporter gene (TauT) by p53 in renal cells. | Han, X., et al. 2002. J Biol Chem. 277: 39266-73. PMID: 12163498
- Regulation of the expression and subcellular localization of the taurine transporter TauT in mouse NIH3T3 fibroblasts. | Voss, JW., et al. 2004. Eur J Biochem. 271: 4646-58. PMID: 15606752
- Physiological significance of the taurine transporter and taurine biosynthetic enzymes in 3T3-L1 adipocytes. | Takasaki, M., et al. 2004. Biofactors. 21: 419-21. PMID: 15630240
- Influence of standard haemodialysis treatment on transcription of human serum- and glucocorticoid-inducible kinase SGK1 and taurine transporter TAUT in blood leukocytes. | Friedrich, B., et al. 2005. Nephrol Dial Transplant. 20: 768-74. PMID: 15701671
- High expression of the taurine transporter TauT in primary cilia of NIH3T3 fibroblasts. | Christensen, ST., et al. 2005. Cell Biol Int. 29: 347-51. PMID: 15914036
- Biallelic mutation of human SLC6A6 encoding the taurine transporter TAUT is linked to early retinal degeneration. | Preising, MN., et al. 2019. FASEB J. 33: 11507-11527. PMID: 31345061
- Involvement of TauT/SLC6A6 in Taurine Transport at the Blood-Testis Barrier. | Kubo, Y., et al. 2022. Metabolites. 12: PMID: 35050188
- Mammalian monocarboxylate transporter 7 (MCT7/Slc16a6) is a novel facilitative taurine transporter. | Higuchi, K., et al. 2022. J Biol Chem. 298: 101800. PMID: 35257743
- Structural Studies of the Taurine Transporter: A Potential Biological Target from the GABA Transporter Subfamily in Cancer Therapy. | Stary, D. and Bajda, M. 2024. Int J Mol Sci. 25: PMID: 39000444
- Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta. | Ramamoorthy, S., et al. 1994. Biochem J. 300 (Pt 3): 893-900. PMID: 8010975
- Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells. | Jhiang, SM., et al. 1993. FEBS Lett. 318: 139-44. PMID: 8382624
- Isolation of a cDNA encoding a taurine transporter in the human retinal pigment epithelium. | Miyamoto, Y., et al. 1996. Curr Eye Res. 15: 345-9. PMID: 8654117
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TAUT Antibody (A-11) | sc-393036 | 200 µg/ml | $322.00 | |||
TAUT Antibody (A-11) AC | sc-393036 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TAUT Antibody (A-11) HRP | sc-393036 HRP | 200 µg/ml | $322.00 | |||
TAUT Antibody (A-11) FITC | sc-393036 FITC | 200 µg/ml | $336.00 | |||
TAUT Antibody (A-11) PE | sc-393036 PE | 200 µg/ml | $349.00 | |||
TAUT Antibody (A-11) Alexa Fluor® 488 | sc-393036 AF488 | 200 µg/ml | $364.00 | |||
TAUT Antibody (A-11) Alexa Fluor® 546 | sc-393036 AF546 | 200 µg/ml | $364.00 | |||
TAUT Antibody (A-11) Alexa Fluor® 594 | sc-393036 AF594 | 200 µg/ml | $364.00 | |||
TAUT Antibody (A-11) Alexa Fluor® 647 | sc-393036 AF647 | 200 µg/ml | $364.00 | |||
TAUT Antibody (A-11) Alexa Fluor® 680 | sc-393036 AF680 | 200 µg/ml | $364.00 | |||
TAUT Antibody (A-11) Alexa Fluor® 790 | sc-393036 AF790 | 200 µg/ml | $364.00 |