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Taurolidine (CAS 19388-87-5) - chemical structure image
Molecular structure of Taurolidine, CAS Number: 19388-87-5
Taurolidine (CAS 19388-87-5) - chemical structure image
Molecular structure of Taurolidine, CAS Number: 19388-87-5
Taurolidine: sc-202827. Western blot analysis of ATF-3 expression in untreated (A) and Taurolidine treated (B) HT-1080 who
Taurolidine: sc-202827. Western blot analysis of ATF-3 expression in untreated (A) and Taurolidine treated (B) HT-1080 whole cell lysates. Note upregulation of ATF-3 expression in lane B. Antibody tested: ATF-3 (C-19): sc-188.
Molecular structure of Taurolidine, CAS Number: 19388-87-5

Taurolidine (CAS 19388-87-5)

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Alternate Names:
Taurolin; Tauroline
Application:
Taurolidine is an antibiotic
CAS Number:
19388-87-5
Purity:
≥98%
Molecular Weight:
284.36
Molecular Formula:
C7H16N4O4S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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SDS & Certificate of Analysis

Taurolidine is a synthetic compound that has been the subject of extensive research due to its interesting chemical properties and interactions. In the field of microbiology, it is studied for its ability to interact with bacterial cell wall components, which can affect bacterial adhesion and biofilm formation. Chemists are interested in taurolidine because of its potential to release reactive intermediates that can engage in various chemical reactions. Researchers also investigate the compound′s role in modulating cellular signaling pathways, particularly focusing on its effects on the production of certain cytokines and other signaling molecules. Additionally, taurolidine is used in the study of its interaction with proteins and enzymes, which can shed light on the mechanisms by which it influences cellular processes.


Taurolidine (CAS 19388-87-5) References

  1. Taurolidine inhibits tumor cell growth in vitro and in vivo.  |  McCourt, M., et al. 2000. Ann Surg Oncol. 7: 685-91. PMID: 11034247
  2. Taurolidine: cytotoxic and mechanistic evaluation of a novel antineoplastic agent.  |  Calabresi, P., et al. 2001. Cancer Res. 61: 6816-21. PMID: 11559556
  3. Taurolidine--a new drug with anti-tumor and anti-angiogenic effects.  |  Jacobi, CA., et al. 2005. Anticancer Drugs. 16: 917-21. PMID: 16162968
  4. Synergistic effects in apoptosis induction by taurolidine and TRAIL in HCT-15 colon carcinoma cells.  |  Chromik, AM., et al. 2007. J Invest Surg. 20: 339-48. PMID: 18097875
  5. Synergistic apoptotic effects of taurolidine and TRAIL on squamous carcinoma cells of the esophagus.  |  Daigeler, A., et al. 2008. Int J Oncol. 32: 1205-20. PMID: 18497982
  6. Taurolidine and catheter-related bloodstream infection: a systematic review of the literature.  |  Bradshaw, JH. and Puntis, JW. 2008. J Pediatr Gastroenterol Nutr. 47: 179-86. PMID: 18664870
  7. The antibacterial substance taurolidine exhibits anti-neoplastic action based on a mixed type of programmed cell death.  |  Stendel, R., et al. 2009. Autophagy. 5: 194-210. PMID: 19066471
  8. The effects of taurolidine alone and in combination with doxorubicin or carboplatin in canine osteosarcoma in vitro.  |  Marley, K., et al. 2013. BMC Vet Res. 9: 15. PMID: 23331343
  9. Preventing catheter-related bacteremia with taurolidine-citrate catheter locks: a systematic review and meta-analysis.  |  Liu, H., et al. 2014. Blood Purif. 37: 179-87. PMID: 24777144
  10. In vitro activity of taurolidine gel on bacteria associated with periodontitis.  |  Eick, S., et al. 2016. Clin Oral Investig. 20: 597-606. PMID: 26254142
  11. In-vitro effects of taurolidine alone and in combination with mitoxantrone and/or piroxicam on canine transitional cell carcinoma.  |  Byer, B., et al. 2020. Can J Vet Res. 84: 115-123. PMID: 32255906
  12. Autophagy induced by taurolidine protects against polymicrobial sepsis by promoting both host resistance and disease tolerance.  |  Huang, J., et al. 2022. Proc Natl Acad Sci U S A. 119: e2121244119. PMID: 35512102
  13. Exploring the potential of taurolidine in inducing mobilization and detachment of colon cancer cells: a preliminary in-vitro study.  |  Mikolajczyk, A., et al. 2022. BMC Pharmacol Toxicol. 23: 38. PMID: 35698168
  14. The Antiseptic and Antineoplastic Agent Taurolidine Modulates Key Leukocyte Functions.  |  Wouters, Y., et al. 2022. In Vivo. 36: 2074-2082. PMID: 36099103
  15. Taurolidine, an antilipopolysaccharide agent, has immunoregulatory properties that are mediated by the amino acid taurine.  |  Watson, RW., et al. 1995. J Leukoc Biol. 58: 299-306. PMID: 7665985

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Taurolidine, 10 mg

sc-202827
10 mg
$52.00

Taurolidine, 50 mg

sc-202827A
50 mg
$176.00

What analytical method was used to obtain [Purity : ≥98%] ? and, Is the water content checked?

Asked by: Kwon
Thank you for your question. This is lot-specific information. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact our Technical Service Department to inquire about the purity of our most recent lot. Please call our Asian Support office toll-free at 800-820-8626, email asia@scbio.cn, or contact us by live chat.
Answered by: Technical Support
Date published: 2017-08-02
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Rated 5 out of 5 by from A large increase in ATFA large increase in ATF-3 protein expression was observed by WB in HT-1080 cells after treatment with Taurolidine. -SCBT QC
Date published: 2015-04-27
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Taurolidine is rated 5.0 out of 5 by 1.
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