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Tauro β-Muricholic Acid Sodium Salt (CAS 25696-60-0) - chemical structure image
Molecular structure of Tauro β-Muricholic Acid Sodium Salt, CAS Number: 25696-60-0
Tauro β-Muricholic Acid Sodium Salt (CAS 25696-60-0) - chemical structure image
Molecular structure of Tauro β-Muricholic Acid Sodium Salt, CAS Number: 25696-60-0
Molecular structure of Tauro β-Muricholic Acid Sodium Salt, CAS Number: 25696-60-0

Tauro β-Muricholic Acid Sodium Salt (CAS 25696-60-0)

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Alternate Names:
Tauro β-Muricholic Acid Sodium Salt is alos known as Tauro-β-muricholate.
Application:
Tauro β-Muricholic Acid Sodium Salt is a steroid and FXR receptor antagonist, used for cholestasis research.
CAS Number:
25696-60-0
Molecular Weight:
537.69
Molecular Formula:
C26H44NO7S•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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SDS & Certificate of Analysis

Tauro β-Muricholic Acid Sodium Salt is a steroid used for cholestasis research. Tauro β-Muricholic Acid Sodium Salt acts as a competitive and reversible antagonist of the farnesoid X receptor (FXR). Tauro β-Muricholic Acid Sodium Salt also works on the taurine-conjugated form of the murine-specific primary bile acid, β-muricholic acid. In germ-free mice, Tauro β-Muricholic Acid Sodium Salt can accumulate under normal conditions, but will reduce upon colonization with human feces.


Tauro β-Muricholic Acid Sodium Salt (CAS 25696-60-0) References

  1. Tauro-β-muricholic acid restricts bile acid-induced hepatocellular apoptosis by preserving the mitochondrial membrane potential.  |  Denk, GU., et al. 2012. Biochem Biophys Res Commun. 424: 758-64. PMID: 22809502
  2. Farnesoid X Receptor Regulation of the NLRP3 Inflammasome Underlies Cholestasis-Associated Sepsis.  |  Hao, H., et al. 2017. Cell Metab. 25: 856-867.e5. PMID: 28380377
  3. Reduction in hepatic secondary bile acids caused by short-term antibiotic-induced dysbiosis decreases mouse serum glucose and triglyceride levels.  |  Kuno, T., et al. 2018. Sci Rep. 8: 1253. PMID: 29352187
  4. Coordinated cytochrome P450 expression in mouse liver and intestine under different dietary conditions during liver regeneration after partial hepatectomy.  |  Fujino, C., et al. 2019. Toxicol Appl Pharmacol. 370: 133-144. PMID: 30880217
  5. Changes in Bile Acid Concentrations after Administration of Ketoconazole or Rifampicin to Chimeric Mice with Humanized Liver.  |  Sanoh, S., et al. 2019. Biol Pharm Bull. 42: 1366-1375. PMID: 31366871
  6. Intestine-specific FXR agonists as potential therapeutic agents for colorectal cancer.  |  Yin, Y., et al. 2021. Biochem Pharmacol. 186: 114430. PMID: 33556338
  7. The immunotoxicity, but not anti-tumor efficacy, of anti-CD40 and anti-CD137 immunotherapies is dependent on the gut microbiota.  |  Blake, SJ., et al. 2021. Cell Rep Med. 2: 100464. PMID: 35028606
  8. Multiple anti-non-alcoholic steatohepatitis (NASH) efficacies of isopropylidenyl anemosapogenin via farnesoid X receptor activation and TFEB-mediated autophagy.  |  Zhang, N., et al. 2022. Phytomedicine. 102: 154148. PMID: 35576742
  9. Capsaicin regulates lipid metabolism through modulation of bile acid/gut microbiota metabolism in high-fat-fed SD rats.  |  Gong, T., et al. 2022. Food Nutr Res. 66: PMID: 35721805
  10. Bile acids target mitofusin 2 to differentially regulate innate immunity in physiological versus cholestatic conditions.  |  Che, Y., et al. 2023. Cell Rep. 42: 112011. PMID: 36656708
  11. Assessing acute colitis induced by dextran sulfate sodium in rats and its impact on gastrointestinal fluids.  |  Klitgaard, M., et al. 2023. Drug Deliv Transl Res.. PMID: 36913104
  12. A radioimmunoassay for tauro-beta-muricholic acid suitable for use with isolated rat liver cells.  |  Botham, KM., et al. 1983. FEBS Lett. 151: 19-21. PMID: 6825837
  13. The metabolism of chenodeoxycholic acid to beta-muricholic acid in rat liver.  |  Botham, KM. and Boyd, GS. 1983. Eur J Biochem. 134: 191-6. PMID: 6861760

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tauro β-Muricholic Acid Sodium Salt, 0.5 mg

sc-361829
0.5 mg
$412.00

Tauro β-Muricholic Acid Sodium Salt, 2.5 mg

sc-361829A
2.5 mg
$1463.00

Tauro β-Muricholic Acid Sodium Salt, 10 mg

sc-361829B
10 mg
$5208.00

Tauro β-Muricholic Acid Sodium Salt, 25 mg

sc-361829C
25 mg
$11971.00

What is the purity of this product?

Asked by: Alison930
Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact our Technical Service Department to inquire about the purity of our most recent lot.
Answered by: Technical Support
Date published: 2019-01-26

Do you have Tauro-β-muricholic Acid (sodium salt) in stock? Thank you.

Asked by: Felice
Thank you for your question. Please contact our Customer Care Department for current product availability.
Answered by: Technical Support
Date published: 2019-01-26

Desired solvent: How can a stock solution be prepared from it? It is soluble in Ethanol?

Asked by: Jz28sail
Thank you for your question. sc-361829, Tauro ∫-Muricholic Acid Sodium Salt is sparingly soluble in ethanol which may be used to prepare a stock solution.
Answered by: Chemical Support 5
Date published: 2018-01-04
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Rated 5 out of 5 by from DawsonDawson, PA. (PubMed 26045273) found that blocking ileal apical membrane bile acid transport (Asbt-null mice) increases fecal bile acid excretion, hepatic Cyp7a1 expression, and the relative proportion of taurocholate in the bile acid pool, but decreases ileal FGF15 expression, bile acid pool size, and hepatic cholesterol content. In contrast, blocking ileal basolateral membrane bile acid transport (Ost -null mice) increases ileal FGF15 expression, reduces hepatic Cyp7a1 expression, and increases the proportion of Tauro- -muricholic acid in the bile acid pool. -SCBT Publication Review
Date published: 2015-01-29
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Tauro β-Muricholic Acid Sodium Salt is rated 5.0 out of 5 by 1.
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