Tauro-α-muricholic acid sodium salt (CAS 25613-05-2 (free base))
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Alternate Names:
N-(3α,6β,7α-Trihydroxy-5β-cholan-24-oyl)-taurine Sodium Salt
CAS Number:
25613-05-2 (free base)
Molecular Weight:
537.68
Molecular Formula:
C26H44NO7S•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tauro-α-muricholic Acid Sodium Salt is a bile acid released from the liver typically used for cholestasis studies. The mechanism of action of this compound is multifaceted, involving multiple pathways. Studies have demonstrated its ability to activate diverse signaling pathways, such as the nuclear factor kappa B (NF-κB) pathway and the peroxisome proliferator-activated receptor alpha (PPARα) pathway. Additionally, it exerts an influence on the gut microbiota, leading to alterations in the composition and functionality of the microbial community.
Tauro-α-muricholic acid sodium salt (CAS 25613-05-2 (free base)) References
- Effect of bile duct ligation on bile acid composition in mouse serum and liver. | Zhang, Y., et al. 2012. Liver Int. 32: 58-69. PMID: 22098667
- Glycyrrhizin and glycyrrhetinic acid inhibits alpha-naphthyl isothiocyanate-induced liver injury and bile acid cycle disruption. | Wang, H., et al. 2017. Toxicology. 386: 133-142. PMID: 28549656
- Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation. | Tian, J., et al. 2017. Sci Rep. 7: 8938. PMID: 28827769
- Targeted Metabolomics Reveals a Protective Role for Basal PPARα in Cholestasis Induced by α-Naphthylisothiocyanate. | Dai, M., et al. 2018. J Proteome Res. 17: 1500-1508. PMID: 29498526
- Ingestion of difructose anhydride III partially suppresses the deconjugation and 7α-dehydroxylation of bile acids in rats fed with a cholic acid-supplemented diet. | Lee, DG., et al. 2019. Biosci Biotechnol Biochem. 83: 1329-1335. PMID: 30912732
- Turnover of bile acids in liver, serum and caecal content by high-fat diet feeding affects hepatic steatosis in rats. | Tang, Y., et al. 2019. Biochim Biophys Acta Mol Cell Biol Lipids. 1864: 1293-1304. PMID: 31170503
- The protective effect and mechanism of the FXR agonist obeticholic acid via targeting gut microbiota in non-alcoholic fatty liver disease. | Zhang, DY., et al. 2019. Drug Des Devel Ther. 13: 2249-2270. PMID: 31308634
- Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis. | Song, X., et al. 2020. Nature. 577: 410-415. PMID: 31875848
- Male-biased fasting-induced changes in hepatic tauro-cholic acid and plasma cholesterol in Sult2a8-haplodeficient mice. | Wang, K., et al. 2020. Transgenic Res. 29: 499-510. PMID: 33029720
- Bile acid profiles in bile and feces of obese mice by a high-performance liquid chromatography-tandem mass spectrometry. | Zheng, J., et al. 2021. Biotechnol Appl Biochem. 68: 1332-1341. PMID: 33140486
- Sodium butyrate alleviates cholesterol gallstones by regulating bile acid metabolism. | Ye, X., et al. 2021. Eur J Pharmacol. 908: 174341. PMID: 34273384
- The compound enzymatic hydrolysate of Neoporphyra haitanensis improved hyperglycemia and regulated the gut microbiome in high-fat diet-fed mice. | Cheng, X., et al. 2022. Food Funct. 13: 6777-6791. PMID: 35667104
- Black raspberry extract can lower serum LDL cholesterol via modulation of gut microbial composition and serum bile acid profile in rats fed trimethylamine-N-oxide with a high-fat diet. | Lim, T., et al. 2022. Food Sci Biotechnol. 31: 1041-1051. PMID: 35873380
- Retraction: Metabolomics reveals that PPARα activation protects against lithocholic acid-induced liver injury. | Zhao, Q., et al. 2023. RSC Adv. 13: 4121. PMID: 36757294
- Assessing acute colitis induced by dextran sulfate sodium in rats and its impact on gastrointestinal fluids. | Klitgaard, M., et al. 2023. Drug Deliv Transl Res.. PMID: 36913104
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tauro-α-muricholic acid sodium salt, 1 mg | sc-475050 | 1 mg | $926.00 | |||
Tauro-α-muricholic acid sodium salt, 2.5 mg | sc-475050A | 2.5 mg | $1564.00 | |||
Tauro-α-muricholic acid sodium salt, 25 mg | sc-475050B | 25 mg | $11965.00 |