Molecular structure of Taspine, CAS Number: 602-07-3
Taspine (CAS 602-07-3)
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Alternate Names:
1-[2-(Dimethylamino)ethyl]-3,8-dimethoxy-[1]benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione; Thaspine
Application:
Taspine is an immunomodulator and AChE inhibitor that has shown to inhibit of the activity of tumor angiogenesis in vitro
CAS Number:
602-07-3
Molecular Weight:
369.37
Molecular Formula:
C20H19NO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Taspine is an immunomodulator and AChE inhibitor that has shown to inhibit of the activity of tumor angiogenesis in vitro. Taspine has shown properties of bacteriostaticity and cytotoxicity. Taspine, a dimeric quinazoline alkaloid, is thought to function as a cyclooxygenase-2 (COX-2) enzyme inhibitor. This enzyme plays a role in inflammation and the synthesis of prostaglandins.
Taspine (CAS 602-07-3) References
- Taspine downregulates VEGF expression and inhibits proliferation of vascular endothelial cells through PI3 kinase and MAP kinase signaling pathways. | Zhao, J., et al. 2008. Biomed Pharmacother. 62: 383-9. PMID: 17826025
- Taspine isolated from Radix et Rhizoma Leonticis inhibits growth of human umbilical vein endothelial cell (HUVEC) by inducing its apoptosis. | Zhang, Y., et al. 2008. Phytomedicine. 15: 112-9. PMID: 17976967
- Suppression of tumor-induced angiogenesis by taspine isolated from Radix et Rhizoma Leonticis and its mechanism of action in vitro. | Zhang, Y., et al. 2008. Cancer Lett. 262: 103-13. PMID: 18180095
- Taspine isolated from Radix et Rhizoma Leonticis inhibits proliferation and migration of endothelial cells as well as chicken chorioallantoic membrane neovascularisation. | Zhang, Y., et al. 2008. Vascul Pharmacol. 48: 129-37. PMID: 18304881
- Activity of taspine isolated from Radix et Rhizoma Leonticis against estrogen-receptor-positive breast cancer. | Zhan, Y., et al. 2011. Fitoterapia. 82: 896-902. PMID: 21605638
- Anti-proliferative and apoptotic effects of the novel taspine derivative tas41 in the Caco-2 cell line. | Zhang, Y., et al. 2011. Environ Toxicol Pharmacol. 31: 406-15. PMID: 21787711
- Revealing multi-binding sites for taspine to VEGFR-2 by cell membrane chromatography zonal elution. | Du, H., et al. 2012. J Chromatogr B Analyt Technol Biomed Life Sci. 887-888: 67-72. PMID: 22321409
- Croton lechleri sap and isolated alkaloid taspine exhibit inhibition against human melanoma SK23 and colon cancer HT29 cell lines. | Montopoli, M., et al. 2012. J Ethnopharmacol. 144: 747-53. PMID: 23123266
- A novel taspine derivative suppresses human liver tumor growth and invasion in vitro and in vivo. | Wang, N., et al. 2013. Oncol Lett. 6: 855-859. PMID: 24137425
- Novel taspine derivative 12k inhibits cell growth and induces apoptosis in lung cell carcinoma. | Dai, B., et al. 2015. Biomed Pharmacother. 70: 227-33. PMID: 25776505
- Taspine derivative TAS9 regulates cell growth and metastasis of human hepatocellular carcinoma. | Liu, R., et al. 2015. Mol Med Rep. 12: 7735-41. PMID: 26459497
- Taspine is the cicatrizant principle in Sangre de Grado extracted from Croton lechleri. | Vaisberg, AJ., et al. 1989. Planta Med. 55: 140-3. PMID: 2748730
- Novel findings to the biosynthetic pathway of magnoflorine and taspine through transcriptomic and metabolomic analysis of Croton draco (Euphorbiaceae). | Canedo-Téxon, A., et al. 2019. BMC Plant Biol. 19: 560. PMID: 31852435
- Taspine is a natural product that suppresses P2X4 receptor activity via phosphoinositide 3-kinase inhibition. | Nadzirin, IB., et al. 2021. Br J Pharmacol. 178: 4859-4872. PMID: 34398973
- Enhancement of wound healing by the alkaloid taspine defining mechanism of action. | Porras-Reyes, BH., et al. 1993. Proc Soc Exp Biol Med. 203: 18-25. PMID: 8386382
Inhibitor of:
AChE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Taspine, 5 mg | sc-396728 | 5 mg | $572.00 | |||
Taspine, 50 mg | sc-396728A | 50 mg | $3131.00 |