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TAPSO Free Acid (CAS 68399-81-5)

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Alternate Names:
TAPSO Free Acid is also known as 2-Hydroxy-3-[tris(hydroxymethyl)methylamino]-1-propanesulfonic acid.
Application:
TAPSO Free Acid is a biological buffer (zwitterionic) useful in cell culture media formulations
CAS Number:
68399-81-5
Purity:
≥99%
Molecular Weight:
259.3
Molecular Formula:
C7H17NO7S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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TAPSO Free Acid, or N-tris(hydroxymethyl)methyl-3-aminopropanesulfonic acid, is a vital chemical compound extensively utilized in scientific research due to its exceptional buffering properties and versatility in various experimental settings. One of its primary mechanisms of action lies in its role as a zwitterionic buffer with a pKa near physiological pH, allowing for precise pH control in biochemical and molecular biology studies. TAPSO Free Acid effectively maintains a stable pH environment, crucial for the stability and activity of biological molecules such as enzymes and proteins during experimental procedures. Its buffering capacity ensures optimal conditions for enzymatic reactions, cell culture maintenance, and nucleic acid manipulation. Additionally, TAPSO Free Acid finds applications in electrophoresis techniques, where it serves as a running buffer for the separation and analysis of biomolecules based on size and charge. Moreover, TAPSO Free Acid is utilized in protein purification and chromatography, acting as a mobile phase buffer for the isolation and purification of biomolecules. Furthermore, it is employed in the preparation of biochemical reagents and analytical standards, ensuring the accuracy and reproducibility of experimental results. Overall, TAPSO Free Acid is a fundamental compound in scientific research, owing to its buffering capabilities and broad utility in various research applications spanning biochemistry, molecular biology, electrophoresis, protein purification, and analytical chemistry.


TAPSO Free Acid (CAS 68399-81-5) References

  1. Interpretation of non-Nernstian slopes in graphic analysis of data collected in pH range close to deprotonation of a ligand Part I. A glass electrode potentiometric and polarographic study of Cd-(TAPSO)x-(OH)y and Zn-(TAPSO)x-(OH)y systems.  |  Machado, CM., et al. 2006. Talanta. 68: 819-30. PMID: 18970396
  2. Effect of phosphate on the kinetics and specificity of glycation of protein.  |  Watkins, NG., et al. 1987. J Biol Chem. 262: 7207-12. PMID: 3584112
  3. Hydrogen ion buffers for biological research.  |  Good, NE., et al. 1966. Biochemistry. 5: 467-77. PMID: 5942950
  4. Interactions of hydroxyl radicals with tris (hydroxymethyl) aminomethane and Good's buffers containing hydroxymethyl or hydroxyethyl residues produce formaldehyde.  |  Shiraishi, H., et al. 1993. Free Radic Res Commun. 19: 315-21. PMID: 8314112
  5. Buffer interactions: Densities and solubilities of some selected biological buffers in water and in aqueous 1,4-dioxane solutions  |  Mohamed Taha, Ming-Jer Lee. 2009. Biochemical Engineering Journal. 46: 334-344.
  6. Buffer interactions: Solubilities and transfer free energies of TRIS, TAPS, TAPSO, and TABS from water to aqueous ethanol solutions  |  Mohamed Taha, Ming-Jer Lee. 2010. Fluid Phase Equilibria. 289: 122-128.
  7. Interactions of bovine serum albumin with biological buffers, TES, TAPS, and TAPSO in aqueous solutions  |  Bhupender S. Gupta, Mohamed Taha, Ming-Jer Lee. 2013. Process Biochemistry. 48: 1686-1696.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

TAPSO Free Acid, 100 g

sc-296445
100 g
$60.00

TAPSO Free Acid, 250 g

sc-296445B
250 g
$130.00

TAPSO Free Acid, 1 kg

sc-296445A
1 kg
$480.00