Molecular structure of TAPI-2, CAS Number: 187034-31-7
TAPI-2 (CAS 187034-31-7)
See product citations (15)
Alternate Names:
TAPI-2 also known as IC3; N-(R)-(2-(Hydroxyaminocarbonyl)methyl)-4-methylpentanoyl-L-t-butyl-glycine-L-alanine 2-aminoethyl amide; 2-aminoethyl Amide; TNF-α Protease Inhibitor-2
Application:
TAPI-2 is a metalloproteinase inhibitor effective against TACE, ADAMs, ACE secretase and other MMPs
CAS Number:
187034-31-7
Molecular Weight:
415.53
Molecular Formula:
C19H37N5O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
TAPI-2 is a hydroxamic acid-based inhibitor that targets tumor necrosis factor-α converting enzyme (TACE), also known as ADAM17, which plays a significant role in the shedding of membrane-bound proteins. This compound is extensively used in research to study the regulation of ectodomain shedding, a process critical for the maturation and release of cytokines, growth factors, and receptors. By inhibiting TACE, TAPI-2 allows researchers to analyze the consequences of blocking the release of these proteins on cell signaling and immune responses. Additionally, TAPI-2 is applied in investigating the underlying mechanisms of conditions where ADAM17 activity is dysregulated. It acts as a useful tool for dissecting the contributions of proteolytic shedding to cellular communication and pathology.
TAPI-2 (CAS 187034-31-7) References
- Interleukin-1beta enhances nucleotide-induced and alpha-secretase-dependent amyloid precursor protein processing in rat primary cortical neurons via up-regulation of the P2Y(2) receptor. | Kong, Q., et al. 2009. J Neurochem. 109: 1300-10. PMID: 19317852
- ADAM17 promotes glioma cell malignant phenotype. | Zheng, X., et al. 2012. Mol Carcinog. 51: 150-64. PMID: 21480393
- Cyclosporin A and tacrolimus induce renal Erk1/2 pathway via ROS-induced and metalloproteinase-dependent EGF-receptor signaling. | Akool, el-S., et al. 2012. Biochem Pharmacol. 83: 286-95. PMID: 22100870
- Autocrine effect of EGFR ligands on the pro-inflammatory response induced by PM(2.5) exposure in human bronchial epithelial cells. | Ramgolam, K., et al. 2012. Arch Toxicol. 86: 1537-46. PMID: 22581348
- Enhanced potency of the metalloprotease inhibitor TAPI-2 by multivalent display. | Raissi, AJ., et al. 2014. Bioorg Med Chem Lett. 24: 2002-7. PMID: 24581919
- Hyperoxia downregulates angiotensin-converting enzyme-2 in human fetal lung fibroblasts. | Oarhe, CI., et al. 2015. Pediatr Res. 77: 656-62. PMID: 25665060
- Transmembrane TNF-dependent uptake of anti-TNF antibodies. | Deora, A., et al. 2017. MAbs. 9: 680-695. PMID: 28323513
- CD9 regulates keratinocyte migration by negatively modulating the sheddase activity of ADAM17. | Liu, J., et al. 2019. Int J Biol Sci. 15: 493-506. PMID: 30745837
- Cyclosporin A activates human hepatocellular carcinoma (HepG2 cells) proliferation: implication of EGFR-mediated ERK1/2 signaling pathway. | Abo-El Fetoh, ME., et al. 2020. Naunyn Schmiedebergs Arch Pharmacol. 393: 897-908. PMID: 31907582
- Identification of novel substrates of a disintegrin and metalloprotease 17 by specific labeling of surface proteins. | Omoteyama, K., et al. 2020. Heliyon. 6: e05804. PMID: 33385093
- ADAM17 Mediates Hypoxia-Induced Keratinocyte Migration via the p38/MAPK Pathway. | Zhu, G., et al. 2021. Biomed Res Int. 2021: 8328216. PMID: 34746310
- Immunomodulatory receptor VSIG4 is released during spontaneous bacterial peritonitis and predicts short-term mortality. | Reißing, J., et al. 2022. JHEP Rep. 4: 100391. PMID: 34917912
- Angiotensin-converting enzyme secretase is inhibited by zinc metalloprotease inhibitors and requires its substrate to be inserted in a lipid bilayer. | Parvathy, S., et al. 1997. Biochem J. 327 (Pt 1): 37-43. PMID: 9355732
Inhibitor of:
ACE, ADAM, ADAM11, ADAM18, ADAM20, ADAM23, ADAM29, ADAM30, ADAM6A, ADAM6B, ADAMTS-L5, CEACAM16, CPA4, Filamin β, HEG1, Integrin M, Intra-acrosomal protein, Mast Cell Protease 4, Mast Cell Protease 9, MBLAC2, Meprin A, Meprin A alpha, MMP, murinoglobulin 1, pilD, SSc5D, and TACE.Activator of:
ADAM21, ADAM24, ADAM8, cathepsin Q, Integrin αX, and Meprin A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TAPI-2, 1 mg | sc-205851 | 1 mg | $286.00 | |||
TAPI-2, 5 mg | sc-205851A | 5 mg | $1019.00 |