Molecular structure of Tanshinone IIA, CAS Number: 568-72-9
Tanshinone IIA (CAS 568-72-9)
See product citations (22)
Application:
Tanshinone IIA is a transcription factor inhibitor
CAS Number:
568-72-9
Purity:
≥97%
Molecular Weight:
294.33
Molecular Formula:
C19H18O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tanshinone IIA is utilized in the field of biochemical research where it plays a significant role in studying cellular pathways and gene expression. Researchers explore its impact on various signaling mechanisms such as those involved in oxidative stress and apoptosis. In laboratory applications, Tanshinone IIA is often used in experiments focusing on its interaction with molecular targets that regulate cell cycle and inflammation. Its ability to modulate enzyme activity is also a key area of study, particularly in understanding how it influences enzymes involved in metabolic processes. Additionally, Tanshinone IIA is used in research aimed at elucidating its role in cellular differentiation and proliferation.
Tanshinone IIA (CAS 568-72-9) References
- Tanshinone IIA, an ingredient of Salvia miltiorrhiza BUNGE, induces apoptosis in human leukemia cell lines through the activation of caspase-3. | Sung, HJ., et al. 1999. Exp Mol Med. 31: 174-8. PMID: 10630370
- Inhibition of interleukin-12 and interferon-gamma production in immune cells by tanshinones from Salvia miltiorrhiza. | Kang, BY., et al. 2000. Immunopharmacology. 49: 355-61. PMID: 10996033
- Tanshinone IIA from Salvia miltiorrhiza inhibits inducible nitric oxide synthase expression and production of TNF-alpha, IL-1beta and IL-6 in activated RAW 264.7 cells. | Jang, SI., et al. 2003. Planta Med. 69: 1057-9. PMID: 14735448
- Tanshinone IIA from Salvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP-9 activity through AKT signaling pathway. | Jin, UH., et al. 2008. J Cell Biochem. 104: 15-26. PMID: 17979138
- Tanshinone IIA induces apoptosis in human lung cancer A549 cells through the induction of reactive oxygen species and decreasing the mitochondrial membrane potential. | Chiu, TL. and Su, CC. 2010. Int J Mol Med. 25: 231-6. PMID: 20043132
- Regulation of adhesion molecules expression in TNF-α-stimulated brain microvascular endothelial cells by tanshinone IIA: involvement of NF-κB and ROS generation. | Tang, C., et al. 2011. Phytother Res. 25: 376-80. PMID: 20687137
- Tanshinone IIA protects against heart failure post-myocardial infarction via AMPKs/mTOR-dependent autophagy pathway. | Zhang, X., et al. 2019. Biomed Pharmacother. 112: 108599. PMID: 30798134
- Tanshinone IIA induces ferroptosis in gastric cancer cells through p53-mediated SLC7A11 down-regulation. | Guan, Z., et al. 2020. Biosci Rep. 40: PMID: 32776119
- Pharmacological Activity and Mechanism of Tanshinone IIA in Related Diseases. | Guo, R., et al. 2020. Drug Des Devel Ther. 14: 4735-4748. PMID: 33192051
- Prospective therapeutic potential of Tanshinone IIA: An updated overview. | Ansari, MA., et al. 2021. Pharmacol Res. 164: 105364. PMID: 33285229
- A comprehensive review of tanshinone IIA and its derivatives in fibrosis treatment. | Bi, Z., et al. 2021. Biomed Pharmacother. 137: 111404. PMID: 33761617
- Tanshinone IIA: A phytochemical as a promising drug candidate for neurodegenerative diseases. | Subedi, L. and Gaire, BP. 2021. Pharmacol Res. 169: 105661. PMID: 33971269
- Tanshinone IIA inhibits gastric cancer cell stemness through inducing ferroptosis. | Ni, H., et al. 2022. Environ Toxicol. 37: 192-200. PMID: 34661962
- Tanshinone IIA: Pharmacology, Total Synthesis, and Progress in Structure-modifications. | Huang, X., et al. 2022. Curr Med Chem. 29: 1959-1989. PMID: 34749607
- Tanshinone IIA: New Perspective on the Anti-Tumor Mechanism of A Traditional Natural Medicine. | Zhang, W., et al. 2022. Am J Chin Med. 50: 209-239. PMID: 34983327
Inhibitor of:
14-3-3 σ, ANKRD10, AP1, ARHGAP10, BLVRB, c-Fos, c-Jun, CKIP-1, ERBIN, ESAT6, Fc ε RIγ, Fos B, G6PT, HNF-1β, HSF3, JAB1, NALP13, NF-E2 p18, NFκB p65, Nucleoredoxin, PCM1, PU.1, RUNX1, SCARF (scavenger receptor class F), SHOX2A, TIAR, TIM-1, TRAF2, TrxR1, USF-1, V-ATPase A2, V1RF2, V1RF3, WDR33, and WISP-2.Activator of:
claudin-5, CLDN (Claudin), Integrin α8, Integrin β6, LIMK-1, NQO1, SRPK1, SUMO-1, TRIM6, USP5, ZBTB43, and ZBTB7C.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tanshinone IIA, 5 mg | sc-200932 | 5 mg | $86.00 | |||
Tanshinone IIA, 25 mg | sc-200932A | 25 mg | $310.00 |