Molecular structure of Tangeretin, CAS Number: 481-53-8
Tangeretin (CAS 481-53-8)
Application:
Tangeretin is a methoxyflavone with antiproliferative effects
CAS Number:
481-53-8
Molecular Weight:
372.4
Molecular Formula:
C20H20O7
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tangeretin is a methoxyflavone compound found in citrus fruits that demonstrates antiproliferative and antioxidant effects. Tangeretin is described to block cell cycle progression at G1 in MDA-MB-435, MCF-7, and HT-29 cell lines. In human T47D cells, Tangeretin was demonstrated to inhibit ERK1/2 (extracellular-signal-regulated kinases 1/2) phosphorylation. Antioxidant activity is as reported with Tangeretin, and it was demonstrated to suppress induction of COX-2 mRNA by IL-1B and to block IL-1B-induced production of COX-2 in A549 cells.
Tangeretin (CAS 481-53-8) References
- Antiproliferative activity of flavonoids on several cancer cell lines. | Kawaii, S., et al. 1999. Biosci Biotechnol Biochem. 63: 896-9. PMID: 10380632
- Tangeretin inhibits extracellular-signal-regulated kinase (ERK) phosphorylation. | Van Slambrouck, S., et al. 2005. FEBS Lett. 579: 1665-9. PMID: 15757658
- Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells. | Chen, KH., et al. 2007. Biochem Pharmacol. 73: 215-27. PMID: 17067555
- Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cells. | Morley, KL., et al. 2007. Cancer Lett. 251: 168-78. PMID: 17197076
- Tangeretin ameliorates erectile and testicular dysfunction in a rat model of hypertension. | Chiangsaen, P., et al. 2020. Reprod Toxicol. 96: 1-10. PMID: 32479886
- Tangeretin inhibits fungal ferroptosis to suppress rice blast. | Liang, M., et al. 2021. J Integr Plant Biol. 63: 2136-2149. PMID: 34570416
- Tangeretin prevents obesity by modulating systemic inflammation, fat browning, and gut microbiota in high-fat diet-induced obese C57BL/6 mice. | Chen, Q., et al. 2022. J Nutr Biochem. 101: 108943. PMID: 35017003
- Tangeretin Synergizes with 5-Fluorouracil to Induce Autophagy through MicroRNA-21 in Colorectal Cancer Cells. | Bai, Y., et al. 2022. Am J Chin Med. 50: 1681-1701. PMID: 35848125
- Tangeretin Protects Mice from Alcohol-Induced Fatty Liver by Activating Mitophagy through the AMPK-ULK1 Pathway. | Guo, J., et al. 2022. J Agric Food Chem. 70: 11236-11244. PMID: 36063077
- Flavonoids (apigenin, tangeretin) counteract tumor promoter-induced inhibition of intercellular communication of rat liver epithelial cells. | Chaumontet, C., et al. 1997. Cancer Lett. 114: 207-10. PMID: 9103293
Inhibitor of:
UGT1A7.Activator of:
RBP-Jκ, UGT1A6, UGT2B10, UGT2B11, UGT2B28, and UGT2B4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tangeretin, 10 mg | sc-202826 | 10 mg | $422.00 |