TALL-1 Antibody (6F2): sc-32773

TALL-1 Antibody (6F2) is a mouse monoclonal IgM antibody that detects the TALL-1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). TALL-1 Antibody (6F2) is available in both non-conjugated and various conjugated forms, including phycoerythrin (PE) and fluorescein isothiocyanate (FITC). TALL-1, also known as B-cell activating factor (BAFF), is a type II membrane protein belonging to the tumor necrosis factor (TNF) cytokine family, and plays a crucial role in the immune system. TALL-1 is predominantly expressed in peripheral blood leukocytes, monocytes, and macrophages, where TALL-1 is essential for regulating immune responses, including infections, inflammation, and autoimmune diseases. Notably, TALL-1 is a potent B cell stimulatory factor that promotes B cell proliferation and survival, making TALL-1 a key player in B cell-associated autoimmune disorders. TALL-1′s structure features a C-terminal extracellular domain with a jelly roll topology, which is vital for ligand trimerization. This structural characteristic facilitates the binding of TALL-1 to its receptors, leading to oligomerization and the initiation of downstream signaling pathways that are critical for immune function. Understanding TALL-1′s role in these processes is important for developing therapeutic strategies targeting autoimmune diseases and enhancing immune responses.

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TALL-1 Antibody (6F2) References:

1. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens.  |  Shu, HB., et al. 1999. J Leukoc Biol. 65: 680-3. PMID: 10331498
2. Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase.  |  Mukhopadhyay, A., et al. 1999. J Biol Chem. 274: 15978-81. PMID: 10347144
3. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.  |  Schneider, P., et al. 1999. J Exp Med. 189: 1747-56. PMID: 10359578
4. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator.  |  Moore, PA., et al. 1999. Science. 285: 260-3. PMID: 10398604
5. Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice.  |  Khare, SD., et al. 2000. Proc Natl Acad Sci U S A. 97: 3370-5. PMID: 10716715
6. The role of TALL-1 and APRIL in immune regulation.  |  Khare, SD. and Hsu, H. 2001. Trends Immunol. 22: 61-3. PMID: 11286694
7. Identification of downstream genes up-regulated by the tumor necrosis factor family member TALL-1.  |  Xu, LG., et al. 2002. J Leukoc Biol. 72: 410-6. PMID: 12149433
8. The level of BLyS (BAFF) correlates with the titre of autoantibodies in human Sjögren's syndrome.  |  Mariette, X., et al. 2003. Ann Rheum Dis. 62: 168-71. PMID: 12525388
9. Ligand-receptor binding revealed by the TNF family member TALL-1.  |  Liu, Y., et al. 2003. Nature. 423: 49-56. PMID: 12721620
10. TNF ligands: is TALL-1 a trimer or a virus-like cluster?  |  Zhukovsky, EA., et al. 2004. Nature. 427: 413-4; discussion 414. PMID: 14749821
11. The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death.  |  Smith, CA., et al. 1994. Cell. 76: 959-62. PMID: 8137429
12. APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth.  |  Hahne, M., et al. 1998. J Exp Med. 188: 1185-90. PMID: 9743536

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TALL-1 Antibody (6F2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-TALL-1 Antibody (6F2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TALL-1 Antibody (6F2) Specifications

Alternate Product Name: TALL-1

Product Clone Name: 6F2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: TALL-1

Epitope Species: human

Product Reactivity/Detection: TALL-1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for TALL-1 Antibody (6F2): FITC: Fluoroscein, PE: Phycoerythrin