TALK-2 Antibody (A-5): sc-393384
- TALK-2 Antibody (A-5) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- raised against amino acids 226-332 mapping near the C-terminus of TALK-2 of human origin
- recommended for detection of TALK-2 of human origin by WB, IP, IF and ELISA
- m-IgG3 BP-HRP is the preferred secondary detection reagent for TALK-2 Antibody (A-5) for WB applications. This reagent is now offered in a bundle with TALK-2 Antibody (A-5) (see ordering information below).
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TALK-2 Antibody (A-5) is a mouse monoclonal IgG3 antibody that detects TALK-2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TALK-2 is a member of the two-pore domain potassium channel family, which plays a crucial role in regulating cell excitability and maintaining the resting membrane potential. TALK-2 is predominantly expressed in the exocrine pancreas and the Langerhans islets, with lower expression levels found in the liver, placenta, heart, and lung. The unique structure of TALK-2, characterized by four transmembrane domains, allows selective conduction of potassium ions, which is vital for various physiological processes, including insulin secretion and neuronal signaling. TALK-2 is strongly activated by nitric oxide and dithiothreitol, highlighting potential roles in cellular signaling pathways and importance in understanding mechanisms underlying pancreatic function and excitability in other tissues. Anti-TALK-2 antibody (A-5) serves as an essential tool for researchers investigating physiological and pathological roles of this potassium channel in human health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TALK-2 Antibody (A-5) | sc-393384 | 200 µg/ml | $322.00 | |||
TALK-2 Antibody (A-5): m-IgG3 BP-HRP Bundle | sc-550490 | 200 µg Ab; 40 µg BP | $361.00 |