Tak1L Antibody (G-8): sc-515478
- Tak1L Antibody (G-8) is a mouse monoclonal IgG2b κ Tak1L antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 79-96 within an internal region of Tak1L of human origin
- Tak1L Antibody (G-8) is recommended for detection of Tak1L of human origin by WB, IP, IF and ELISA
- Anti-Tak1L Antibody (G-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Tak1L Antibody (G-8). This work is in progress.
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Tak1L Antibody (G-8) is a mouse monoclonal IgG2b kappa light chain antibody that detects Tak1L protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Tak1L (G-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Tak1L protein, also known as C21orf7, is a 242 amino acid protein that shares significant homology with the C-terminal tail of Tak1, a key player in the TGFβ signaling pathway. Tak1L is predominantly expressed in peripheral blood leukocytes and shows strong expression in adenocarcinomic cell lines such as GI-112 and PC-3, as well as in the carcinomic cell line GI-101. Understanding Tak1L structure is crucial, as Tak1L is believed to play a role in modulating the activity of other kinases involved in signal transduction, particularly in the context of cancer biology. Structural similarities between Tak1 and Tak1L suggest Tak1L may also participate in the activation of the mitogen-activated protein kinase (MAPK) pathway, which is essential for various cellular processes, including proliferation, differentiation, and apoptosis. Using anti-Tak1L antibody (G-8) in research can provide insights into Tak1L functional roles and potential implications in disease mechanisms, particularly in cancer.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Tak1L Antibody (G-8) References:
- Cloning and characterization of a novel human TGF-beta activated kinase-like gene. | Li, J., et al. 2004. Biochem Genet. 42: 129-37. PMID: 15168726
- Protein kinase cascades in meiotic and mitotic cell cycle control. | Pelech, SL., et al. 1990. Biochem Cell Biol. 68: 1297-330. PMID: 2085430
- Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity. | Morrison, DK., et al. 1988. Proc Natl Acad Sci U S A. 85: 8855-9. PMID: 3057494
- Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo. | Ray, LB. and Sturgill, TW. 1988. Proc Natl Acad Sci U S A. 85: 3753-7. PMID: 3287375
- Characterization of murine A-raf, a new oncogene related to the v-raf oncogene. | Huleihel, M., et al. 1986. Mol Cell Biol. 6: 2655-62. PMID: 3491291
- KSR: a novel player in the RAS pathway. | Downward, J. 1995. Cell. 83: 831-4. PMID: 8521506
- KSR, a novel protein kinase required for RAS signal transduction. | Therrien, M., et al. 1995. Cell. 83: 879-88. PMID: 8521512
- The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction. | Sundaram, M. and Han, M. 1995. Cell. 83: 889-901. PMID: 8521513
- Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. | Yamaguchi, K., et al. 1995. Science. 270: 2008-11. PMID: 8533096
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tak1L Antibody (G-8) | sc-515478 | 200 µg/ml | $322.00 | |||
Tak1L Antibody (G-8) AC | sc-515478 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Tak1L Antibody (G-8) HRP | sc-515478 HRP | 200 µg/ml | $322.00 | |||
Tak1L Antibody (G-8) FITC | sc-515478 FITC | 200 µg/ml | $336.00 | |||
Tak1L Antibody (G-8) PE | sc-515478 PE | 200 µg/ml | $349.00 | |||
Tak1L Antibody (G-8) Alexa Fluor® 488 | sc-515478 AF488 | 200 µg/ml | $364.00 | |||
Tak1L Antibody (G-8) Alexa Fluor® 546 | sc-515478 AF546 | 200 µg/ml | $364.00 | |||
Tak1L Antibody (G-8) Alexa Fluor® 594 | sc-515478 AF594 | 200 µg/ml | $364.00 | |||
Tak1L Antibody (G-8) Alexa Fluor® 647 | sc-515478 AF647 | 200 µg/ml | $364.00 | |||
Tak1L Antibody (G-8) Alexa Fluor® 680 | sc-515478 AF680 | 200 µg/ml | $364.00 | |||
Tak1L Antibody (G-8) Alexa Fluor® 790 | sc-515478 AF790 | 200 µg/ml | $364.00 | |||
Tak1L (G-8) Neutralizing Peptide | sc-515478 P | 100 µg/0.5 ml | $69.00 |