TAG-72 Antibody (CC49): sc-20043
- TAG-72 Antibody (CC49) is a mouse monoclonal IgG1 κ TAG-72 antibody, cited in 4 publications, provided at 200 µg/ml
- raised against purified TAG-72 of human origin
- TAG-72 Antibody (CC49) is recommended for detection of TAG-72 of broad species origin by WB, IP, IF, IHC(P) and FCM
- Anti-TAG-72 Antibody (CC49) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TAG-72 Antibody (CC49). This work is in progress.
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SEE ALSO...
TAG-72 Antibody (CC49) is a mouse monoclonal IgG1 kappa light chain antibody that detects TAG-72 protein across multiple species through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). TAG-72 (CC49) antibody is available in non-conjugated form and various conjugates, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® dyes. Tumor-associated glycoprotein 72 (TAG-72) is a high molecular weight glycoprotein found in cytoplasm and cell membranes of malignant cells, serving as a crucial cancer diagnostic marker. TAG-72 shows high expression in 80% of colorectal carcinomas but rarely appears in normal epithelial tissues and benign conditions, making TAG-72 valuable for therapeutic targeting. TAG-72 expression is significant in low-grade mucoepidermoid carcinomas and various gynecologic malignancies, including epithelial ovarian and endometrial carcinomas. In human prostatic adenocarcinomas, TAG-72 expression negatively correlates with Gleason grade differentiation, indicating involvement in tumor progression. TAG-72 presence in gastric, esophageal, pancreatic, and non-small cell lung carcinomas demonstrates broad significance across multiple cancer types. TAG-72′s role in purifying primary ovarian cancer cells from patient ascites further proves valuable for research and clinical applications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TAG-72 Antibody (CC49) References:
- An immunomagnetic-based method for the purification of ovarian cancer cells from patient-derived ascites. | Barker, SD., et al. 2001. Gynecol Oncol. 82: 57-63. PMID: 11426962
- Expression of tumor-associated glycoprotein-72 (TAG-72) antigen in human prostatic adenocarcinomas. | Karan, D., et al. 2001. Oncol Rep. 8: 1123-6. PMID: 11496328
- Expression of TAG-72 in ovarian cancer and its correlation with tumor stage and patient prognosis. | Ponnusamy, MP., et al. 2007. Cancer Lett. 251: 247-57. PMID: 17210225
- Identification of a high affinity TAG-72 binding peptide by phage display selection. | Xiao, N., et al. 2011. Cancer Biol Ther. 11: 22-31. PMID: 20980835
- Tumor-associated glycoprotein (TAG-72) is a natural ligand for the C-type lectin-like domain that induces anti-inflammatory orientation of early pregnancy decidual CD1a+ dendritic cells. | Laskarin, G., et al. 2011. J Reprod Immunol. 88: 12-23. PMID: 21172564
- In Vivo Pretargeted Imaging of HER2 and TAG-72 Expression Using the HaloTag Enzyme. | Knight, JC., et al. 2017. Mol Pharm. 14: 2307-2313. PMID: 28505463
- The use of monoclonal antibody B72.3 in the management of gynecologic malignancies. | Simpson, J. and Schlom, J. 1988. Yale J Biol Med. 61: 351-66. PMID: 3055701
- Distribution of oncofetal antigen tumor-associated glycoprotein-72 defined by monoclonal antibody B72.3. | Thor, A., et al. 1986. Cancer Res. 46: 3118-24. PMID: 3516392
- Tumor-associated glycoprotein expression in salivary gland mucoepidermoid carcinomas: an immunohistochemical study using the monoclonal antibody B72.3. | Roa, RA., et al. 1994. Laryngoscope. 104: 304-8. PMID: 8127187
- TAG-72 (CA 72-4 assay) as a complementary serum tumor antigen to carcinoembryonic antigen in monitoring patients with colorectal cancer. | Guadagni, F., et al. 1993. Cancer. 72: 2098-106. PMID: 8374868
- TAG-72 expression and its role in the biological evaluation of human colorectal cancer. | Guadagni, F., et al. 1996. Anticancer Res. 16: 2141-8. PMID: 8694534
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TAG-72 Antibody (CC49) | sc-20043 | 200 µg/ml | $322.00 | |||
TAG-72 Antibody (CC49) AC | sc-20043 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TAG-72 Antibody (CC49) HRP | sc-20043 HRP | 200 µg/ml | $322.00 | |||
TAG-72 Antibody (CC49) FITC | sc-20043 FITC | 200 µg/ml | $336.00 | |||
TAG-72 Antibody (CC49) PE | sc-20043 PE | 200 µg/ml | $349.00 | |||
TAG-72 Antibody (CC49) Alexa Fluor® 488 | sc-20043 AF488 | 200 µg/ml | $364.00 | |||
TAG-72 Antibody (CC49) Alexa Fluor® 546 | sc-20043 AF546 | 200 µg/ml | $364.00 | |||
TAG-72 Antibody (CC49) Alexa Fluor® 594 | sc-20043 AF594 | 200 µg/ml | $364.00 | |||
TAG-72 Antibody (CC49) Alexa Fluor® 647 | sc-20043 AF647 | 200 µg/ml | $364.00 | |||
TAG-72 Antibody (CC49) Alexa Fluor® 680 | sc-20043 AF680 | 200 µg/ml | $364.00 | |||
TAG-72 Antibody (CC49) Alexa Fluor® 790 | sc-20043 AF790 | 200 µg/ml | $364.00 |