Molecular structure of Tafluprost (free acid), CAS Number: 209860-88-8
Tafluprost (free acid) (CAS 209860-88-8)
Alternate Names:
(5E)-7-{2-[(1E)-3,3-Difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl}-5-heptenoic acid
Application:
Tafluprost (free acid) is a very strong FP receptor agonist
CAS Number:
209860-88-8
Molecular Weight:
410.45
Molecular Formula:
C22H28F2O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tafluprost (free acid) is a member of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives of research interest for in vitro glaucoma studies. Tafluprost is a 2-series, 16-phenoxy analog of PGF2α with the 15,15-difluoro substitution. Tafluprost (free acid) is a very strong PGF2αR (FP receptor) agonist, with a Ki of 0.4 nM.
Tafluprost (free acid) (CAS 209860-88-8) References
- The pharmacology of bimatoprost (Lumigan). | Woodward, DF., et al. 2001. Surv Ophthalmol. 45 Suppl 4: S337-45. PMID: 11434936
- The hydrolysis of bimatoprost in corneal tissue generates a potent prostanoid FP receptor agonist. | Maxey, KM., et al. 2002. Surv Ophthalmol. 47 Suppl 1: S34-40. PMID: 12204699
- Pharmacological characteristics of AFP-168 (tafluprost), a new prostanoid FP receptor agonist, as an ocular hypotensive drug. | Takagi, Y., et al. 2004. Exp Eye Res. 78: 767-76. PMID: 15037111
- Disposition and metabolism of a novel prostanoid antiglaucoma medication, tafluprost, following ocular administration to rats. | Fukano, Y. and Kawazu, K. 2009. Drug Metab Dispos. 37: 1622-34. PMID: 19477946
- Metabolism and ocular tissue distribution of an antiglaucoma prostanoid, tafluprost, after ocular instillation to monkeys. | Fukano, Y., et al. 2011. J Ocul Pharmacol Ther. 27: 251-9. PMID: 21491995
- Neuroprotective effects of prostaglandin analogues on retinal ganglion cell death independent of intraocular pressure reduction. | Yamagishi, R., et al. 2011. Exp Eye Res. 93: 265-70. PMID: 21791206
- Drug metabolite heterogeneity in cultured single cells profiled by pico-trapping direct mass spectrometry. | Fukano, Y., et al. 2012. Nanomedicine (Lond). 7: 1365-74. PMID: 22583577
- In vitro Effects of Prostaglandin Analogs on Cultured Astrocytes Obtained from the Lamina Cribrosa. | Shin, JA., et al. 2016. Curr Eye Res. 41: 676-82. PMID: 26237412
- Benefits of Tafluprost and Timolol Fixed-Dose Combination for the Treatment of Glaucoma Are Confirmed by Studies on Experimental Animal Models. | Akaishi, T., et al. 2015. J Ocul Pharmacol Ther. 31: 518-24. PMID: 26325164
- Advantages of Efficacy and Safety of Fixed-Dose Tafluprost/Timolol Combination Over Fixed-Dose Latanoprost/Timolol Combination. | Fuwa, M., et al. 2016. PLoS One. 11: e0158797. PMID: 27383260
- Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2 alpha receptor. Implications for development of a photoaffinity probe. | Balapure, AK., et al. 1989. Biochem Pharmacol. 38: 2375-81. PMID: 2751699
- A Novel Convergent Synthesis of the Potent Antiglaucoma Agent Tafluprost. | Krupa, M., et al. 2017. Molecules. 22: PMID: 28146132
- The Sustained Release of Tafluprost with a Drug Delivery System Prevents the Axonal Injury-induced Loss of Retinal Ganglion Cells in Rats. | Sato, K., et al. 2020. Curr Eye Res. 45: 1114-1123. PMID: 31994948
- Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor. | Lake, S., et al. 1994. FEBS Lett. 355: 317-25. PMID: 7988697
- Phenyl-substituted prostaglandins: potent and selective antiglaucoma agents. | Resul, B., et al. 1993. J Med Chem. 36: 243-8. PMID: 8423596
Activator of:
PGF2alphaR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tafluprost (free acid), 1 mg | sc-205516 | 1 mg | $140.00 | |||
Tafluprost (free acid), 5 mg | sc-205516A | 5 mg | $630.00 |