Tafluprost CAS: 209860-87-7
MF: C25H34F2O5
MW: 452.54
An FP receptor agonist.

Tafluprost (CAS 209860-87-7)

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Alternate Names: AFP-168
Application: Tafluprost is an FP receptor agonist
CAS Number: 209860-87-7
Molecular Weight: 452.54
Molecular Formula: C25H34F2O5
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Tafluprost is a very potent prostaglandin F (FP) receptor agonist (Ki = 0.4 nM). Tafluprost is a 2-series, 16-phenoxy analog of PGFwith the 15,15-difluoro substitution.


References

1. Resul, B., et al., 1993. Phenyl-substituted prostaglandins: potent and selective antiglaucoma agents. Journal of medicinal chemistry. 36(2): 243-8. PMID: 8423596
2. Abramovitz, M., et al., 2000. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochimica et biophysica acta. 1483(2): 285-93. PMID: 10634944
3. Woodward, D F., et al., 2001. The pharmacology of bimatoprost (Lumigan). Survey of ophthalmology. 45 Suppl 4(): S337-45. PMID: 11434936
4. Maxey, Kirk M., et al., 2002. The hydrolysis of bimatoprost in corneal tissue generates a potent prostanoid FP receptor agonist. Survey of ophthalmology. 47 Suppl 1(): S34-40. PMID: 12204699
5. Nakajima, Tadashi., et al., 2003. New fluoroprostaglandin F(2alpha) derivatives with prostanoid FP-receptor agonistic activity as potent ocular-hypotensive agents. Biological & pharmaceutical bulletin. 26(12): 1691-5. PMID: 14646172

Formulation :
A solution in methyl acetate
Physical State :
Liquid
Solubility :
Soluble in ethanol (≥30 mg/ml), DMSO (≥30 mg/ml), DMF (≥30 mg/ml), and 1:1 solution of ethanol:PBS (pH 7.2) (0.5 mg/ml).
Storage :
Store at -20° C
Boiling Point :
57° C
Refractive Index :
n20D 1.55 (Predicted)
Ki Data :
FP receptor: Ki= 0.4 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 1231, Class 3, Packing group II
PubChem CID :
9868491
MDL Number :
MFCD08062150
SMILES :
CC(C)OC(=O)CCC/C=C\C[[email protected]]1[[email protected]](C[[email protected]]([[email protected]@H]1/C=C/C(COC2=CC=CC=C2)(F)F)O)O

Download SDS (MSDS)

Certificate of Analysis

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