TAF II p68 Antibody (TAF15B11A6): sc-81121

TAF II p68 Antibody (TAF15B11A6) is a mouse monoclonal IgG1 antibody that detects TAF II p68 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-TAF II p68 antibody (TAF15B11A6) is available as a non-conjugated format. TAF II p68, also known as TAF15, RBP56, or TAF2N, plays a crucial role in regulating gene expression as a member of the RNA polymerase II multiprotein complex, which is essential for transcribing protein-coding genes. TAF II p68 is primarily located in the nucleus, where TAF II p68 interacts with various transcription factors and components of the transcription machinery, facilitating preinitiation complex assembly at target gene promoter regions. Proper localization of TAF II p68 is vital for function, ensuring correct positioning of transcriptional machinery to initiate RNA synthesis. Additionally, TAF II p68 shares homology with TLS (translocated in liposarcoma) and EWS (Ewing′s sarcoma), both implicated in oncogenic processes. When fused with certain transcription factors, TAF II p68 can act as an oncoprotein, contributing to malignancies such as extraskeletal myxoid chondrosarcoma. TAF II p68′s ability to bind single-stranded RNA further underscores importance in post-transcriptional regulation, making TAF II p68 a significant target for research in cancer biology and gene regulation.

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TAF II p68 Antibody (TAF15B11A6) References:

1. Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11).  |  Panagopoulos, I., et al. 1999. Oncogene. 18: 7594-8. PMID: 10602519
2. The N-terminal domain of human TAFII68 displays transactivation and oncogenic properties.  |  Bertolotti, A., et al. 1999. Oncogene. 18: 8000-10. PMID: 10637511
3. Recurrent rearrangement of the Ewing's sarcoma gene, EWSR1, or its homologue, TAF15, with the transcription factor CIZ/NMP4 in acute leukemia.  |  Martini, A., et al. 2002. Cancer Res. 62: 5408-12. PMID: 12359745
4. Stimulation of hTAFII68 (NTD)-mediated transactivation by v-Src.  |  Lee, HJ., et al. 2004. FEBS Lett. 564: 188-98. PMID: 15094065
5. TLS, EWS and TAF15: a model for transcriptional integration of gene expression.  |  Law, WJ., et al. 2006. Brief Funct Genomic Proteomic. 5: 8-14. PMID: 16769671
6. Regulation of oncogenic transcription factor hTAF(II)68-TEC activity by human glyceraldehyde-3-phosphate dehydrogenase (GAPDH).  |  Kim, S., et al. 2007. Biochem J. 404: 197-206. PMID: 17302560
7. hTAF(II)68, a novel RNA/ssDNA-binding protein with homology to the pro-oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II.  |  Bertolotti, A., et al. 1996. EMBO J. 15: 5022-31. PMID: 8890175
8. Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes.  |  Morohoshi, F., et al. 1998. Gene. 221: 191-8. PMID: 9795213

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TAF II p68 Antibody (TAF15B11A6) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-TAF II p68 Antibody (TAF15B11A6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TAF II p68 Antibody (TAF15B11A6) Specifications

Alternate Product Name: TAF II p68

Product Clone Name: TAF15B11A6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: TAF II p68

Epitope Species: human

Product Reactivity/Detection: TAF II p68

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for TAF II p68 Antibody (TAF15B11A6): N/A