Molecular structure of Tacalcitol, CAS Number: 57333-96-7
Tacalcitol (CAS 57333-96-7)
Alternate Names:
1alpha,24(R)-Dihydroxyvitamin D3
Application:
Tacalcitol is a synthetic vitamin D3 analog
CAS Number:
57333-96-7
Purity:
≥98%
Molecular Weight:
416.64
Molecular Formula:
C27H44O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tacalcitol is a vitamin D3 analog that functions as a potent agonist of the vitamin D receptor. It exerts its mechanism of action by binding to the vitamin D receptor in target cells, leading to the regulation of gene expression involved in cellular differentiation and proliferation. Tacalcitol modulates the immune response by inhibiting the production of pro-inflammatory cytokines and promoting the production of anti-inflammatory cytokines. Tacalcitol also plays a role in the regulation of calcium and phosphate metabolism by enhancing the absorption of calcium in the intestines and promoting its reabsorption in the kidneys. Tacalcitol may inhibit the proliferation of keratinocytes and promote their differentiation.
Tacalcitol (CAS 57333-96-7) References
- A case of subcorneal pustular dermatosis treated with tacalcitol (1alpha,24-dihydroxyvitamin D3). | Kawaguchi, M., et al. 2000. J Dermatol. 27: 669-72. PMID: 11092273
- Pharmacological profiles of high-concentration (20 microg/g) tacalcitol ointment: effects on cutaneous inflammation, epidermal proliferation, and differentiation in mice. | Sato, H., et al. 2003. J Dermatol. 30: 510-24. PMID: 12928540
- Anti-inflammatory effects of tacalcitol (1,24(R)(OH)2D3, TV-02) in the skin of TPA-treated hairless mice. | Sato, H., et al. 2004. J Dermatol. 31: 200-17. PMID: 15187340
- 1,24-Dihydroxyvitamin D₃ (tacalcitol) prevents skin T-cell infiltration. | Yamanaka, KI., et al. 2010. Br J Dermatol. 162: 1206-15. PMID: 20163421
- Freckling promoted by topical tacalcitol in a Japanese boy with left eyelid vitiligo. | Oiso, N. and Kawada, A. 2012. Pediatr Dermatol. 29: 671-2. PMID: 22011021
- Tacalcitol in the treatment of acquired perforating collagenosis. | Escribano-Stablé, JC., et al. 2014. Case Rep Dermatol. 6: 69-73. PMID: 24707254
- Protective effects of tacalcitol against oxidative damage in human epidermal melanocytes. | Li, QL., et al. 2017. Int J Dermatol. 56: 232-238. PMID: 28074522
- Vitamin D Analogues Tacalcitol and Calcipotriol Inhibit Proliferation and Migration of T98G Human Glioblastoma Cells. | Emanuelsson, I., et al. 2018. Basic Clin Pharmacol Toxicol. 123: 130-136. PMID: 29575677
- Steroid hormone calcitriol and its analog tacalcitol inhibit miR-125b expression in a human breast cancer MCF-7 cell line. | Klopotowska, D., et al. 2019. Steroids. 141: 70-75. PMID: 30503385
- Combination of tacalcitol ointment and photodynamic therapy for the treatment of follicular mucinosis of the scalp. | Giuffrida, R., et al. 2019. Photodiagnosis Photodyn Ther. 27: 487-489. PMID: 31299390
- Divergent Effect of Tacalcitol (PRI-2191) on Th17 Cells in 4T1 Tumor Bearing Young and Old Ovariectomized Mice. | Pawlik, A., et al. 2020. Aging Dis. 11: 241-253. PMID: 32257539
- Therapeutic Options for the Treatment of Darier's Disease: A Comprehensive Review of the Literature. | Hanna, N., et al. 2022. J Cutan Med Surg. 26: 280-290. PMID: 34841914
- The Impact of Exosomes/Microvesicles Derived from Myeloid Dendritic Cells Cultured in the Presence of Calcitriol and Tacalcitol on Acute B-Cell Precursor Cell Lines with MLL Fusion Gene. | Turlej, E., et al. 2022. J Clin Med. 11: PMID: 35456315
- Effects of 1α,25-dihydroxyvitamin D3 and tacalcitol on cell signaling and anchorage-independent growth in T98G and U251 glioblastoma cells. | Olsson, F., et al. 2022. Biochem Biophys Rep. 31: 101313. PMID: 35935021
- Topical tacalcitol (1,24-(R)-dihydroxyvitamin D3) induces a transient increase in thymidine incorporation and calmodulin content in pig epidermis following tape stripping in vivo. | Hashimoto, Y., et al. 1995. J Dermatol Sci. 10: 196-202. PMID: 8593261
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tacalcitol, 1 mg | sc-361371 | 1 mg | $157.00 |