Molecular structure of TACA, CAS Number: 38090-53-8
TACA (CAS 38090-53-8)
Alternate Names:
trans-4-Aminocrotonic acid
Application:
TACA is a GABAA and GABAC agonist
CAS Number:
38090-53-8
Molecular Weight:
101.10
Molecular Formula:
C4H7NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
TACA is a GABAA and GABAC agonist. TACA is also a GABA-T substrate and GABA uptake inhibitor. This compound is a trans-isomer of CACA.
TACA (CAS 38090-53-8) References
- Effects of the conformationally restricted GABA analogues, cis- and trans-4-aminocrotonic acid, on GABA neurotransmission in primary neuronal cultures. | Vale, C., et al. 1999. J Neurosci Res. 57: 95-105. PMID: 10397639
- Taurine release modified by GABAergic agents in hippocampal slices from adult and developing mice. | Saransaari, P. and Oja, SS. 2000. Amino Acids. 18: 17-30. PMID: 10794129
- Correlation of the apparent affinities and efficacies of gamma-aminobutyric acid(C) receptor agonists. | Chang, Y., et al. 2000. Mol Pharmacol. 58: 1375-80. PMID: 11093776
- A comparison of gamma-aminobutyric acid and the semi-rigid analogues 4-aminotetrolic acid, 4-aminocrotonic acid and imidazole-4-acetic acid on the isolated superior cervical ganglion of the rat. | Bowery, NG. and Jones, GP. 1976. Br J Pharmacol. 56: 323-30. PMID: 1260178
- Drosophila melanogaster GRD and LCCH3 subunits form heteromultimeric GABA-gated cation channels. | Gisselmann, G., et al. 2004. Br J Pharmacol. 142: 409-13. PMID: 15148245
- Vigabatrin transport across the human intestinal epithelial (Caco-2) brush-border membrane is via the H+ -coupled amino-acid transporter hPAT1. | Abbot, EL., et al. 2006. Br J Pharmacol. 147: 298-306. PMID: 16331283
- Cis- and trans-4-aminocrotonic acid as GABA analogues of restricted conformation. | Johnston, GA., et al. 1975. J Neurochem. 24: 157-60. PMID: 234147
- Unsaturated Analogues of the Neurotransmitter GABA: trans-4-Aminocrotonic, cis-4-Aminocrotonic and 4-Aminotetrolic Acids. | Johnston, GA. 2016. Neurochem Res. 41: 476-80. PMID: 26012366
- Efficient synthesis of the GABAA receptor agonist trans-4-aminocrotonic acid (TACA). | Forrester, SG., et al. 2017. Bioorg Med Chem Lett. 27: 4512-4513. PMID: 28838689
- Phytochemical Analysis and Central Effects of Annona Muricata Linnaeus: Possible Involvement of the Gabaergic and Monoaminergic Systems. | Souza, DO., et al. 2018. Iran J Pharm Res. 17: 1306-1317. PMID: 30568689
- Transient apnoea after systemic injection of GABA in the rat. | Holzer, P. and Hagmüller, K. 1979. Naunyn Schmiedebergs Arch Pharmacol. 308: 55-60. PMID: 492353
- Pharmacology of GABA receptor Cl- channels in rat retinal bipolar cells. | Feigenspan, A., et al. 1993. Nature. 361: 159-62. PMID: 7678450
- GABAc receptors: relatively simple transmitter -gated ion channels? | Johnston, GA. 1996. Trends Pharmacol Sci. 17: 319-23. PMID: 8885697
- Stimulation of [3H] GABA and beta-[3H] alanine release from rat brain slices by cis-4-aminocrotonic acid. | Chebib, M. and Johnston, GA. 1997. J Neurochem. 68: 786-94. PMID: 9003070
- Analogues of gamma-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists. | Chebib, M., et al. 1997. Br J Pharmacol. 122: 1551-60. PMID: 9422798
Inhibitor of:
GABAA Rβ3.Activator of:
GABA Receptor.Substrate of:
GABA Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TACA, 10 mg | sc-203705 | 10 mg | $94.00 | |||
TACA, 50 mg | sc-203705A | 50 mg | $302.00 |