T62 CAS: 40312-34-3
MF: C15H14ClNOS
MW: 291.80
An allosteric enhancer of A1 adenosine receptor.

T62 (CAS 40312-34-3)

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Alternate Names: 2-Amino-3-(4-chlorobenzoyl)-5,6,7,8-tetrahydrobenzothiophene
Application: T62 is an allosteric enhancer of A1 adenosine receptor
CAS Number: 40312-34-3
Molecular Weight: 291.80
Molecular Formula: C15H14ClNOS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

T62 is an an allosteric enhancer of A1 adenosine receptor. It has been reported that T62 can reverse thermal hypersensitivity in studies of carrageenin-inflamed rats. T62 has also been reported to reduce mechanical allodynia and induce drug tolerance over time in rat models of neuropathic pain.


References

Soudijn, W., et al., Allosteric modulation of G protein-coupled receptors: perspectives and recent developments. Drug Discov. Today 9, 752-758, (2004) Obata, H., et al., Spinal adenosine receptor activation reduces hypersensitivity after surgery by a different mechanism than after nerve injury. Anesthesiology 100, 1258-1262, (2004) Li, X., et al., Allosteric adenosine receptor modulation reduces hypersensitivity following peripheral inflammation by a central mechanism. J. Pharmacol. Exp. Ther. 305, 950-955, (2003)

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in DMSO
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
855908
SMILES :
C1CCC2=C(C1)C(=C(S2)N)C(=O)C3=CC=C(C=C3)Cl

Download SDS (MSDS)

Certificate of Analysis

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