T62 is an an allosteric enhancer of A1 adenosine receptor. It has been reported that T62 can reverse thermal hypersensitivity in studies of carrageenin-inflamed rats. T62 has also been reported to reduce mechanical allodynia and induce drug tolerance over time in rat models of neuropathic pain.
Soudijn, W., et al., Allosteric modulation of G protein-coupled receptors: perspectives and recent developments. Drug Discov. Today 9, 752-758, (2004) Obata, H., et al., Spinal adenosine receptor activation reduces hypersensitivity after surgery by a different mechanism than after nerve injury. Anesthesiology 100, 1258-1262, (2004) Li, X., et al., Allosteric adenosine receptor modulation reduces hypersensitivity following peripheral inflammation by a central mechanism. J. Pharmacol. Exp. Ther. 305, 950-955, (2003)
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