T3JAM Antibody (H-2): sc-398895

T3JAM Antibody (H-2) is a mouse monoclonal IgG1 antibody that detects T3JAM in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). T3JAM, also known as TRAF3-interacting JNK-activating modulator or TRAF3IP3, is a 551 amino acid single-pass type IV membrane protein that plays a crucial role as an adaptor molecule, stimulating cell growth by modulating the c-Jun N-terminal kinase (JNK) pathway in conjunction with TRAF3. T3JAM′s function lies in regulating cellular responses to stress and inflammation, which are critical for maintaining cellular homeostasis and preventing pathological conditions. T3JAM is predominantly expressed in the thymus, bone marrow, and spleen, where T3JAM binds to the isoleucine zipper of TRAF3 through its coiled-coil domain, ensuring specificity in interactions. T3JAM has been shown to associate specifically with TRAF3, distinguishing T3JAM from other TRAF family members, and exists in three isoforms due to alternative splicing events. The gene encoding T3JAM is located on human chromosome 1, a region that harbors genetic aberrations associated with various cancers, including head and neck cancer, malignant melanoma, and multiple myeloma. With unique properties and a critical role in cellular signaling, anti-T3JAM antibody (H-2) serves as an invaluable tool for researchers investigating the JNK pathway and its implications in health and disease.

The preferred T3JAM antibody is T3JAM Antibody (B-7): sc-398781.