Molecular structure of T16Ainh-A01, CAS Number: 552309-42-9
T16Ainh-A01 (CAS 552309-42-9)
Alternate Names:
2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]-acetamide
Application:
T16Ainh-A01 is A selective TMEM16A calcium-activated chloride channel inhibitor that strongly inhibits chloride current in salivary gland cells
CAS Number:
552309-42-9
Molecular Weight:
416.52
Molecular Formula:
C19H20N4O3S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
T16Ainh-A01 is a selective transmembrane protein 16A (TMEM16A) calcium-activated chloride channel (CaCC) inhibitor that strongly inhibits chloride current in salivary gland cells. T16Ainh-A01 was reported to poorly inhibit total CaCC current in intestinal and airway epithelial cells, but block mainly an initial, agonist-stimulated transient chloride current. T16Ainh-A01 does not alter cytoplasmic calcium and has little effect on CFTR Cl- conductance. Its inhibitory effects are independent of voltage and do not prolong the rate of T16Ainh-A01 current deactivation. TMEM16A also blocks CaCC activity in vascular smooth muscle cells and relaxes mouse and human blood vessels. Additionally, it inhibits the proliferation of pancreatic cancer and squamous carcinoma cells in culture.
T16Ainh-A01 (CAS 552309-42-9) References
- Anoctamin-1/TMEM16A is the major apical iodide channel of the thyrocyte. | Twyffels, L., et al. 2014. Am J Physiol Cell Physiol. 307: C1102-12. PMID: 25298423
- TRPC1 regulates calcium-activated chloride channels in salivary gland cells. | Sun, Y., et al. 2015. J Cell Physiol. 230: 2848-56. PMID: 25899321
- Role of anoctamin-1 and bestrophin-1 in spinal nerve ligation-induced neuropathic pain in rats. | Pineda-Farias, JB., et al. 2015. Mol Pain. 11: 41. PMID: 26130088
- Increased TMEM16A Involved in Alveolar Fluid Clearance After Lipopolysaccharide Stimulation. | Li, H., et al. 2016. Inflammation. 39: 881-90. PMID: 26899569
- Local coupling of TRPC6 to ANO1/TMEM16A channels in smooth muscle cells amplifies vasoconstriction in cerebral arteries. | Wang, Q., et al. 2016. Am J Physiol Cell Physiol. 310: C1001-9. PMID: 27147559
- Chloride ion transport and overexpression of TMEM16A in a guinea-pig asthma model. | Kondo, M., et al. 2017. Clin Exp Allergy. 47: 795-804. PMID: 28109183
- TMEM16A inhibition impedes capacitation and acquisition of hyperactivated motility in guinea pig sperm. | Cordero-Martínez, J., et al. 2018. J Cell Biochem. 119: 5944-5959. PMID: 29600587
- Effects of the Calcium-Activated Chloride Channel Inhibitors T16Ainh-A01 and CaCCinh-A01 on Cardiac Fibroblast Function. | Tian, XQ., et al. 2018. Cell Physiol Biochem. 49: 706-716. PMID: 30165368
- Clarithromycin suppresses IL-13-induced goblet cell metaplasia via the TMEM16A-dependent pathway in guinea pig airway epithelial cells. | Hara, K., et al. 2019. Respir Investig. 57: 79-88. PMID: 30393041
- Mechanism of persistent hyperalgesia in neuropathic pain caused by chronic constriction injury. | Chen, QY., et al. 2019. Neural Regen Res. 14: 1091-1098. PMID: 30762024
- Epidermal growth factor upregulates expression of MUC5AC via TMEM16A, in chronic rhinosinusitis with nasal polyps. | Jiao, J., et al. 2020. Allergy Asthma Clin Immunol. 16: 40. PMID: 32514271
- [Effects of T16Ainh-A01 on the apoptosis and senescence of endothelial cells in the cochlea stria vascularis]. | Feng, ZY., et al. 2020. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 36: 385-389. PMID: 33629548
- Anoctamin1 Induces Hyperproliferation of HaCaT Keratinocytes and Triggers Imiquimod-Induced Psoriasis-Like Skin Injury in Mice. | Choi, MR., et al. 2021. Int J Mol Sci. 22: PMID: 34281197
- Blockade of TMEM16A protects against renal fibrosis by reducing intracellular Cl- concentration. | Li, XL., et al. 2022. Br J Pharmacol. 179: 3043-3060. PMID: 34961937
- TMEM16A blockers T16Ainh-A01 and benzbromarone do not modulate the regulation of sweating and cutaneous vasodilatation in humans in vivo. | Fujii, N., et al. 2022. Exp Physiol. 107: 844-853. PMID: 35688020
Inhibitor of:
Bestrophin-3, CLCA5_Clac5, Clca6, CLIC1, Eapa2, LOC388564, Rad52, SLC26A9, TMEM16A, TMEM16C, TMEM16E, TMEM16F, TMEM16H, and TMEM16K.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
T16Ainh-A01, 10 mg | sc-497578 | 10 mg | $68.00 | |||
T16Ainh-A01, 50 mg | sc-497578A | 50 mg | $277.00 |