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T-type Ca<sup>++</sup> CP &alpha;1I Antibody (3H5) - Western Blotting - Image 348981
T-type Ca++ CP α1I (3H5): sc-293486. Western blot analysis of human recombinant T-type Ca++ CP α1I fusion protein.
T-type Ca++ CP α1I Antibody (3H5) - Western Blotting - Image 348981
T-type Ca++ CP α1I (3H5): sc-293486. Western blot analysis of human recombinant T-type Ca++ CP α1I fusion protein.
T-type Ca++ CP α1I (3H5): sc-293486. Western blot analysis of human recombinant T-type Ca++ CP α1I fusion protein.

T-type Ca++ CP α1I Antibody (3H5): sc-293486

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Datasheets
  • T-type Ca++ CP α1I Antibody (3H5) is a mouse monoclonal IgG1 κ T-type Ca++ CP α1I antibody provided at 100 µg/ml
  • raised against amino acids 233-331 representing partial length T-type Ca++ CP α1I of human origin
  • recommended for detection of T-type Ca++ CP α1I of mouse, rat and human origin by WB, IP and ELISA
  • At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for T-type Ca++ CP α1I Antibody (3H5). This work is in progress.

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    Additional Calcium Channel Protein Antibodies including L-type Ca++ CP α 1F, L-type Ca++ CP α 1S, L-type Ca++ CP β 1A, L-type Ca++ CP β 2, L-type Ca++ CP β 3, L-type Ca++ CP β 4, L-type Ca++CP γ 2, L-type Ca++CP γ 3, L-type Ca++CP γ 8 and N-type Ca++ CP α 1B

    T-type Ca++ CP α1I Antibody (3H5) is a mouse monoclonal IgG1 kappa light chain antibody that detects T-type Ca++ CP alpha 1I protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-T-type Ca++ CP α1I antibody (3H5) is available as non-conjugated format. T-type Ca++ CP alpha 1I protein plays a crucial role in modulating calcium ion influx in excitable cells, essential for various physiological processes such as muscle contraction, neurotransmitter release, and gene expression. Located primarily in plasma membrane of neurons and muscle cells, T-type Ca++ CP alpha 1I is part of a larger family of voltage-dependent calcium channels characterized by unique biophysical properties. T-type channels activate and inactivate rapidly at more negative membrane potentials compared to other calcium channel types, contributing to action potential generation and rhythmic firing in neurons. T-type channels enhance sensory perception, such as odor sensitivity, by lowering spike generation threshold in olfactory receptor cells. Understanding T-type Ca++ CP alpha 1I function and dynamics is vital for elucidating roles in both normal physiology and pathological conditions, making T-type Ca++ CP α1I (3H5) monoclonal antibody an invaluable tool for researchers studying calcium signaling pathways.

    For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

    Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

    LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

    T-type Ca++ CP α1I Antibody (3H5) References:

    1. Structure and regulation of voltage-gated Ca2+ channels.  |  Catterall, WA. 2000. Annu Rev Cell Dev Biol. 16: 521-55. PMID: 11031246
    2. Enhancement by T-type Ca2+ currents of odor sensitivity in olfactory receptor cells.  |  Kawai, F. and Miyachi, E. 2001. J Neurosci. 21: RC144. PMID: 11319242
    3. T-type Ca2+ channels and autoregulation of local blood flow.  |  Jensen, LJ., et al. 2017. Channels (Austin). 11: 183-195. PMID: 28055302
    4. T-type Ca2+ Channels: T for Targetable.  |  Sallán, MC., et al. 2018. Cancer Res. 78: 603-609. PMID: 29343521
    5. Cav3 T-Type Voltage-Gated Ca2+ Channels and the Amyloidogenic Environment: Pathophysiology and Implications on Pharmacotherapy and Pharmacovigilance.  |  Papazoglou, A., et al. 2022. Int J Mol Sci. 23: PMID: 35408817
    6. Effects of progesterone on T-type-Ca2+-channel expression in Purkinje cells.  |  Eickhoff, A., et al. 2022. Neural Regen Res. 17: 2465-2471. PMID: 35535898
    7. T-Type Ca2+ Channels Boost Neurotransmission in Mammalian Cone Photoreceptors.  |  Davison, A., et al. 2022. J Neurosci. 42: 6325-6343. PMID: 35803735
    8. T-type Ca2+ channels play a dual role in modulating the excitability of dorsal root ganglia neurons.  |  Zhu, T. and Wang, Y. 2022. Mol Pain. 18: 17448069221132224. PMID: 36163701
    9. L- and T-type Ca2+ channels dichotomously contribute to retinal ganglion cell injury in experimental glaucoma.  |  Wang, HN., et al. 2023. Neural Regen Res. 18: 1570-1577. PMID: 36571364
    10. T-Type Ca2+ Channels Mediate a Critical Period of Plasticity in Adult-Born Granule Cells.  |  Kennedy, WM., et al. 2024. J Neurosci. 44: PMID: 38413230
    11. Molecular biology of calcium channels.  |  Perez-Reyes, E. and Schneider, T. 1995. Kidney Int. 48: 1111-24. PMID: 8569073
    12. The molecular basis of voltage-gated Ca2+ channel diversity: is it time for T?  |  Randall, AD. 1998. J Membr Biol. 161: 207-13. PMID: 9493126

    Ordering Information

    Product NameCatalog #UNITPriceQtyFAVORITES

    T-type Ca++ CP α1I Antibody (3H5)

    sc-293486
    100 µg/ml
    		$316.00

    Do we need different protein extraction method for this antibody. T type Ca channel is a membrane protein could we use standart protocol?

    Asked by: dancer81
    Thank you for your inquiry. We would recommend to follow the sample preparation according to the procedure described in the protocol for Western Blotting. Please find the protocol under the following link: https://www.scbt.com/scbt/resources/protocols/western-immuno-blotting?&amp;_requestid=3815318 For any further questions you may have please contact our Technical Service in our European Support Office in Germany directly. You can reach us by phone at: +49 6221 4503 0, by email at: europe@scbt.com or by live chat on our website, www.scbt.com We are happy to assist you.
    Answered by: Technical Support Europe
    Date published: 2018-01-19

    For Western Blot, is it recommended to use denatured or non-denatured conditions with T-type Ca++ CP &alpha;1I (3H5): sc-293486 antibody?

    Asked by: jerojero
    Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
    Answered by: Technical Support
    Date published: 2017-03-27
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    Rated 5 out of 5 by from Good for Western blotAntibody detects human recombinant T-type Ca++ CP α1I by Western blot. -SCBT QC
    Date published: 2023-09-14
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    T-type Ca ++ CP α1I Antibody (3H5) is rated 5.0 out of 5 by 1.
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