t-Butyl trifluoroacetate (CAS 400-52-2)
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t-Butyl trifluoroacetate is a chemical that sees frequent use in organic synthesis, particularly as a protecting group for alcohols. The t-butyl group is known for its steric bulk, which is beneficial in protecting hydroxyl functionalities during reactions where such functional groups may be otherwise reactive. The trifluoroacetate moiety is a good leaving group, facilitating the deprotection step when the protected alcohol is no longer needed. In research labs, t-Butyl trifluoroacetate is often utilized to study reaction mechanisms where protecting groups are pivotal for the successful synthesis of complex organic molecules. Its volatility and reactivity make it a suitable candidate for reactions that require mild and neutral conditions for deprotection, which is essential for the stability of sensitive molecular structures.
t-Butyl trifluoroacetate (CAS 400-52-2) References
- Deprotection of N(in)-formyl group on tryptophan by application of new reagent, 1,2-dimethylethylendiamine in aqueous solution. | Odagami, T., et al. 2009. Adv Exp Med Biol. 611: 159-60. PMID: 19400139
- Removal of t-butyl and t-butoxycarbonyl protecting groups with trifluoroacetic acid. Mechanisms, biproduct formation and evaluation of scavengers. | Lundt, BF., et al. 1978. Int J Pept Protein Res. 12: 258-68. PMID: 744685
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
t-Butyl trifluoroacetate, 5 g | sc-301859 | 5 g | $104.00 | |||
t-Butyl trifluoroacetate, 25 g | sc-301859A | 25 g | $284.00 |