Syntide-2 Protein Kinase Substrate is a synthetic peptide recognized as a substrate by CaMKII (Ca2+/calmodulin-dependent protein kinase II) enzymes. The sequence of Syntide-2 is homologous to phosphorylation site 2 on glycogen synthase, a target of CaMKII action. Syntide-2 has been used as a probe to assay localization of CaMKII activity and to study the effects of point mutations on phosphorylation activity. Numerous kinase enzymes including CaMKV and Raf-1 are reported to recognize Syntide-2 as a substrate as well, suggesting a wide scope of Syntide-2-assayable systems. Syntide-2, Protein Kinase Substrate is a substrate of Raf-1and PKC.
1. Hashimoto, Y., et al. 1987. Arch. Biochem. Biophys. 252: 418-425. PMID: 3028265 2. Li, P., et al. 1991. Cell. 64: 479-482. PMID: 1846778 3. Mochizuki, H., et al. 1993. J. Biol. Chem. 268: 9143-9147. PMID: 8386178 4. Ishida, A. and Fujisawa, H. 1995. J. Biol. Chem. 270: 2163-2170. PMID: 7836445
Soluble in water, and 1% acetic acid (1 mg/ml).
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For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Various publications have cited the use of SyntideVarious publications have cited the use of Syntide-2, Protein Kinase Substrate as a probe to assay localization of CaMKII activity and to study the effects of point mutations on phosphorylation activity. -SCBT Publication Review
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