syntide-2 substrate: sc-3015

Syntide-2 substrate, a synthetic peptide commonly used in biochemical and cellular studies, serves as a substrate for various protein kinases, particularly protein kinase A (PKA) and protein kinase C (PKC). Its sequence, based on the consensus phosphorylation site of glycogen synthase kinase-3 (GSK-3), allows for specific phosphorylation events to occur at serine residues. By mimicking the natural substrate of GSK-3, syntide-2 facilitates the investigation of kinase activity, substrate specificity, and phosphorylation-dependent signaling pathways involved in cellular processes such as cell growth, proliferation, and differentiation. Research utilizing syntide-2 has contributed significantly to understanding the regulatory mechanisms of GSK-3 and its role in various signaling cascades implicated in diseases such as cancer, diabetes, and neurodegenerative disorders. Furthermore, syntide-2 has been instrumental in the development and validation of novel kinase inhibitors and activators, offering valuable insights into potential strategies targeting aberrant kinase signaling. Its versatility and reliability make syntide-2 substrate a fundamental tool in elucidating the complex mechanisms governing cellular signaling pathways and their dysregulation in pathological conditions, thereby advancing research in both basic and translational sciences.